Potential antitumor agents. 40. Orally active 4,5-disubstituted derivatives of amsacrine

Article abstract of DOI:10.1021/jm00369a021

The DNA-intercalating agent amsacrine is an effective drug for the treatment of human leukemias and lymphomas but has minimal solid tumor activity. As a first step in identifying analogues with a wider spectrum of activity, a comparison was made of the in