Synthesis of α-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors

DOI: 10.1016/j.bmcl.2005.12.082

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1888 - 1891 (2006)

Update date:2022-08-02

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Authors:

Haemers, Timothy

Wiesner, Jochen

Van Poecke, Sara

Goeman, Jan

Henschker, Dajana

Beck, Edwald

Jomaa, Hassan

Van Calenbergh, Serge

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Article abstract of DOI:10.1016/j.bmcl.2005.12.082

In view of the promising antimalarial activity of fosmidomycin or its N-acetyl homologue FR900098, the objective of this work was to investigate the influence of aromatic substituents in the α-position of the phosphonate moiety. The envisaged analogues we

Full text of DOI:10.1016/j.bmcl.2005.12.082

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