A New and Effective Synthetic Method for the Preparation of the Esters, Peptides, and Lactones Using 3-(5-Nitro-2-oxo-1,2-dihydro-1-pyridyl)-1,2-benzisothiazole 1,1-Dioxide. Synthesis of (+/-)-E-Dodecen-11-olide, Recifeiolide

Article abstract of DOI:10.1246/bcsj.57.781

3-(5-nitro-2-oxo-1,2-dihydro-1-pyridyl)-1,2-benzisothiazole 1,1-dioxide (BID-NPy), readily prepared from 3-chloro-1,2-benzisothiazole 1,1-dioxide and 5-nitro-2-pyridone, proved to be a very useful condensing reagent.A variety of esters, dipeptides, and lactones were obtained in excellent yields.Furthemore, BID-NPy was successfully employed for the lactonization step in a new synthesis of a naturally occuring (+/-)-(E)-8-dodecen-11-olide, recifeiolide.