Synthesis of phosphorodithioate DNA by the H-phosphonothioate method

DOI: 10.1016/S0040-4020(99)00241-0

Source and publish data:

Tetrahedron p. 5759 - 5772 (1999)

Update date:2022-08-04

Topics:

Authors:

Seeberger, Peter H.

Caruthers, Marvin H.

Bankaitis-Davis, Danute

Beaton, Graham

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Article abstract of DOI:10.1016/S0040-4020(99)00241-0

A novel method for the efficient synthesis phosphorodithioate DNA using H-phosphonothioate synthons is described. The 5'-DMT-nucleotide H- phosphonothioate monomers were prepared in two high yielding steps, from commercially, available phosphoramidites. T

Full text of DOI:10.1016/S0040-4020(99)00241-0

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