TOTAL SYNTHESIS OF (+/-)-OTONECINE, A NECINE BASE OF PYRROLIZIDINE ALKALOIDS

DOI: 10.1016/S0040-4039(00)94186-8

Source and publish data:

Tetrahedron Letters p. 5731 - 5732 (1983)

Update date:2022-08-02

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Authors:

Niwa, Haruki

Uosaki, Youichi

Yamada, Kiyoyuki

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Article abstract of DOI:10.1016/S0040-4039(00)94186-8

Otonecine (1), a representative necine base of hepatotoxic and carcinogenic pyrrolizidine alkaloids, was synthesized in racemic form from ethyl 1-hydroxy-2,3,5,6-tetrahydro-1H-pyrrolizine-7-carboxylate (5).

Full text of DOI:10.1016/S0040-4039(00)94186-8

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