Journal of Medicinal Chemistry p. 691 - 694 (1984)
Update date:2022-08-04
Topics:
Diana, G. D.
Zalay, E. S.
Salvador, U. J.
Pancic, F.
Steinberg, B.
Several keto phosphonates, phosphonoacetates, and dialkyl phosphonates containing (aryloxy)aryl group were synthesized and evaluated for antiherpetic activity.Two of the most active compounds, 12 and 16, were evaluated topically in the mouse vaginal model against herpes simplex virus (HSV) type 2.Compound 16 exhibited an increased survival rate, as well as increased survival time.Evaluation of 16 in the guinea pig skin test against HSV-2 produced a reduction in virus titer, as well as in mean vesicle score.
View MoreQuzhou Aokai Chemical Co., Ltd.
Contact:86-570-3032832
Address:NO.16 , Laodong Road,Quzhou City, Zhejiang Province,China
shanghai tuomiao chemicial co.,ltd.
website:https://www.tuomiaochem.com/
Contact:021 - 59853336
Address:shanghai
Shijiazhuang Frontierchem Co., Ltd.
Contact:+86-311-89271196
Address:4-4-202 No.15 Biandian Street,Shijiazhuang
WEIFANG RICHEM INTERNATIONAL LTD
Contact:86-536-2222176
Address:weifang,shandong
Changsha Yonta Industry Co., Ltd.
Contact:+ 86-731-8535 2228
Address:Rm.1717, North Bldg., No.368, East 2nd Ring Road(2nd Section)
Doi:10.1021/j150654a026
(1984)Doi:10.1021/om050834w
(2006)Doi:10.1002/ejoc.201300818
(2013)Doi:10.1002/ejoc.201500228
(2015)Doi:10.1039/b703370b
(2007)Doi:10.1021/ja01607a053
(1955)
