REGIOSELECTIVE SYNTHESIS OF 4-(2-OXOALKYL)PYRIDINES VIA 1,4-DIHYDROPYRIDINE DERIVATIVES USING SILYL ENOL ETHERS AND PYRIDINIUM SALTS

DOI: 10.1016/S0040-4039(00)88414-2

Source and publish data:

Tetrahedron Letters p. 5269 - 5272 (1983)

Update date:2022-08-03

Topics:

Authors:

Akiba, Kin-ya

Nishihara, Yoshihiro

Wada, Makoto

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)88414-2

Trimethylsilyl enol ethers (1) reacted with 1-ethoxycarbonylpyridinium chloride (3) at 4-position with high regioselectivity to afford 1-ethoxycarbonyl-4-(2-oxoalkyl)-1,4-dihydropyridines (4) in 42-87percent yields.When 2,2,2-trichloroethyl chloroformate

Full text of DOI:10.1016/S0040-4039(00)88414-2

Products guided by the article

Product name:1(4H)-Pyridinecarboxylic acid, 4-(1-methyl-2-oxo-2-phenylethyl)-, ethyl ester

Cas No:89318-14-9

R&D Labs maybe for 89318-14-9

Shanghai Balmxy Pharmaceutical Co., Ltd

Contact:0086-21-24206007

Address:Room 402, 15#, No. 909 wangyue Road, shanghai, P. R. China
Weihao Chemtech (ChangZhou) Co., Ltd.(expird)

Contact:051989185693

Address:NO 217 huangshan Rd ,Changzhou
Shanghai Topchem Co., LTD

website:http://www.shtopchem.com/

Contact:0086-0576-87776998

Address:room no 1608,xuhui business building yude road,xujiahui street, xuhui district
Jinhua Haoyuan Chemical CO., LTD(expird)

Contact:86-579-82465583

Address:Jinhua,Zhejiang
Shanghai Harvest Chemical Ind. Co., Ltd.

Contact:021-51385350

Address:ROOM 806-807, AI LI CHEN BUILDING, No.333 JINGXIANG ROAD, PUDONG DISTRICT, 201206, SHANGHAI

Relevant to this article

Hydrazine nitrosation of a metal-bound nitric oxide: Structural evidence for the formation of an ammine complex

Doi:10.1021/ic060096j
(2006)
Visible-Light-Driven Neutral Nitrogen Radical Mediated Intermolecular Styrene Difunctionalization

Doi:10.1021/acs.orglett.9b01362
(2019)
Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2 H -benzo[ h ]chromen-2-one and 4-amino-7,8,9,10-tetrahydro- 2 h -benzo[ h ]chromen-2-one analogues with improved water solubility

Doi:10.1021/np2007878
(2012)
Synthesis, crystal and molecular structure of N-(p-chlorobenzylamide) of α-(1,1-ethylenedioxy)-ethyl-γ-hydroxybutyric acid

Doi:10.1007/BF01186251
(1992)
A three-step synthesis of 4-(4-iodo-1H-pyrazol-1-yl)piperidine, a key intermediate in the synthesis of Crizotinib

Doi:10.1016/j.tetlet.2011.12.044
(2012)
Asymmetric Synthesis of Trisubstituted Tetrahydrothiophenes via in Situ Generated Chiral Fluoride-Catalyzed Cascade Sulfa-Michael/Aldol Reaction of 1,4-Dithiane-2,5-diol and α,β-Unsaturated Ketones

Doi:10.1021/acs.orglett.7b00813
(2017)

Article Doi