REGIOSELECTIVE SYNTHESIS OF 4-(2-OXOALKYL)PYRIDINES VIA 1,4-DIHYDROPYRIDINE DERIVATIVES USING SILYL ENOL ETHERS AND PYRIDINIUM SALTS

DOI: 10.1016/S0040-4039(00)88414-2

Source and publish data:

Tetrahedron Letters p. 5269 - 5272 (1983)

Update date:2022-08-03

Topics:

Authors:

Akiba, Kin-ya

Nishihara, Yoshihiro

Wada, Makoto

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)88414-2

Trimethylsilyl enol ethers (1) reacted with 1-ethoxycarbonylpyridinium chloride (3) at 4-position with high regioselectivity to afford 1-ethoxycarbonyl-4-(2-oxoalkyl)-1,4-dihydropyridines (4) in 42-87percent yields.When 2,2,2-trichloroethyl chloroformate

Full text of DOI:10.1016/S0040-4039(00)88414-2

Products guided by the article

Product name:1(4H)-Pyridinecarboxylic acid, 4-(1-methyl-2-oxo-2-phenylethyl)-, ethyl ester

Cas No:89318-14-9

R&D Labs maybe for 89318-14-9

Brichem ( Haikou ) Co. Ltd.

Contact:86-898-65311214

Address:Room 102, BLDG. 68 Jiangnan City, No. 66 Heping Road,Haikou, Hainan, China
Wansheng

Contact:86-21-31200601

Address:Room1618,FangzhengDaSha,No.1122 Xinjinqiao Road,Pudong New District,Shanghai ,China
Okeanos Tech.Co.,LTD

Contact:+86-10-62651721

Address:29 Yongxing Road, Daxing District,Beijing China
SICHUAN ZHONGBANG NEW MATERIAL CO., LTD

website:http://www.zhongbangst.com

Contact:86-830-2585019

Address:sichuan,china
Huaian Double Win Chemicals Co.,Ltd.

Contact:+86-13511538872

Address:Blk 43,Greenland Century Town,Huaian District, Huaian City,Jiangsu Province,China

Relevant to this article

Hydrazine nitrosation of a metal-bound nitric oxide: Structural evidence for the formation of an ammine complex

Doi:10.1021/ic060096j
(2006)
Visible-Light-Driven Neutral Nitrogen Radical Mediated Intermolecular Styrene Difunctionalization

Doi:10.1021/acs.orglett.9b01362
(2019)
Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2 H -benzo[ h ]chromen-2-one and 4-amino-7,8,9,10-tetrahydro- 2 h -benzo[ h ]chromen-2-one analogues with improved water solubility

Doi:10.1021/np2007878
(2012)
Synthesis, crystal and molecular structure of N-(p-chlorobenzylamide) of α-(1,1-ethylenedioxy)-ethyl-γ-hydroxybutyric acid

Doi:10.1007/BF01186251
(1992)
A three-step synthesis of 4-(4-iodo-1H-pyrazol-1-yl)piperidine, a key intermediate in the synthesis of Crizotinib

Doi:10.1016/j.tetlet.2011.12.044
(2012)
Asymmetric Synthesis of Trisubstituted Tetrahydrothiophenes via in Situ Generated Chiral Fluoride-Catalyzed Cascade Sulfa-Michael/Aldol Reaction of 1,4-Dithiane-2,5-diol and α,β-Unsaturated Ketones

Doi:10.1021/acs.orglett.7b00813
(2017)

Article Doi