REGIOSELECTIVE SYNTHESIS OF 4-(2-OXOALKYL)PYRIDINES VIA 1,4-DIHYDROPYRIDINE DERIVATIVES USING SILYL ENOL ETHERS AND PYRIDINIUM SALTS

DOI: 10.1016/S0040-4039(00)88414-2

Source and publish data:

Tetrahedron Letters p. 5269 - 5272 (1983)

Update date:2022-08-03

Topics:

Authors:

Akiba, Kin-ya

Nishihara, Yoshihiro

Wada, Makoto

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Article abstract of DOI:10.1016/S0040-4039(00)88414-2

Trimethylsilyl enol ethers (1) reacted with 1-ethoxycarbonylpyridinium chloride (3) at 4-position with high regioselectivity to afford 1-ethoxycarbonyl-4-(2-oxoalkyl)-1,4-dihydropyridines (4) in 42-87percent yields.When 2,2,2-trichloroethyl chloroformate

Full text of DOI:10.1016/S0040-4039(00)88414-2

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