Visible-light, iodine-promoted formation of n-sulfonyl imines and n-alkylsulfonamides from aldehydes and hypervalent iodine reagents

Article abstract of DOI:10.3390/molecules23081838

Alternative synthetic methodology for the direct installation of sulfonamide functionality is a highly desirable goal within the domain of drug discovery and development. The formation of synthetically valuable N-sulfonyl imines from a range of aldehydes,

Full text of DOI:10.3390/molecules23081838

molecules
Article
Visible-Light, Iodine-Promoted Formation of
N-Sulfonyl Imines and N-Alkylsulfonamides from
Aldehydes and Hypervalent Iodine Reagents
ID
Megan D. Hopkins, Zachary C. Brandeburg, Andrew J. Hanson and Angus A. Lamar *
Department of Chemistry and Biochemistry, The University of Tulsa, 800 S. Tucker Dr., Tulsa, OK 74104, USA;
mdh933@utulsa.edu (M.D.H.); brandeburgz@gmail.com (Z.C.B.); djh758@utulsa.edu (A.J.H.)
* Correspondence: angus-lamar@utulsa.edu; Tel.: +1-918-631-3024
Academic Editor: John C. Walton
ꢀꢁꢂꢀꢃꢄꢅꢆꢇ
ꢀꢁꢂꢃꢄꢅꢆ
Received: 12 July 2018; Accepted: 21 July 2018; Published: 24 July 2018
Abstract: Alternative synthetic methodology for the direct installation of sulfonamide functionality
is a highly desirable goal within the domain of drug discovery and development. The formation of
synthetically valuable N-sulfonyl imines from a range of aldehydes, sulfonamides, and PhI(OAc)2
under practical and mild reaction conditions has been developed. According to mechanistic studies
described within, the reaction proceeds through an initial step involving a radical initiator (generated
either by visible-light or heat) to activate the reacting substrates. The reaction provides a synthetically
useful and operationally simple, relatively mild alternative to the traditional formation of N-sulfonyl
imines that utilizes stable, widely available reagents.
Keywords: visible-light; iodine promoted; N-sulfonyl imine; iodobenzene diacetate (PIDA);
sulfonamide; hypervalent iodine; aldimine synthesis; iminoiodinane; nitrogen-centered radical
1. Introduction
Sulfonamides are a crucial class of bioisosteric building blocks that are prevalent in a wide range
of pharmaceuticals (such as sulfadiazine and amprenavir) and a variety of bioactive compounds
(Figure 1) [1–6]. The incorporation of an N-alkylsulfonamide unit is most frequently accomplished
by the reaction of a sulfonyl chloride with a pre-installed alkyl amine in a basic medium. However,
the direct installation of an entire N-sulfonyl unit provides an attractive option for the drug discovery
and development community to synthesize sulfonamides. With regard to N-sulfonyl incorporation,
recent strategies have devoted attention to the transformation of functionalities other than pre-installed
amines (such as aldehyde) to N-sulfonyl imines. These intermediate imine species can be easily
reduced to N-alkylsulfonamides, effectively circumventing the need for a pre-installed amine.
In addition, N-sulfonyl imines have found use as versatile activated (electron-deficient) electrophiles in
a number of organic transformations, including nucleophilic additions (to form chiral amines) [
cycloadditions [14 17], aza-Friedel–Crafts [18 22], ene reactions [23 26], imino-aldol reactions [27
and C–H functionalizations [31–35].
7
–
–
13],
30],
–
–
–
Molecules 2018, 23, 1838; doi:10.3390/molecules23081838
www.mdpi.com/journal/molecules

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Figure 1. Selected examples of bioactive benzylic N-alkylsulfonamide pharmacores.
Due to the increasing utilization of these electrophilic synthetic intermediates, a variety of methods
to prepare N-sulfonyl imines have been developed in recent years (Scheme 1). The most frequently
employed path for production of an N-sulfonyl aldimine involves the condensation of an aldehyde
and a sulfonamide (Scheme 1, method A). The inherently low nucleophilicity of sulfonamide has
led to disadvantageous conditions that can include (1) the requirement of a harsh Bronsted or Lewis
acid, (2) elevated temperatures (>100 ◦C), (3) difficult purification procedures, and (4) the removal of
water (by chemical or physical means) to achieve carbonyl activation [36–43]. In addition to traditional
approaches of aldehyde/sulfonamide condensation, methods involving the non-dehydrative reaction
of aldehydes with isocyanate analogues have been reported (Scheme 1, method B) [44–46]. Resulting
from our research group’s interest in the utilization of N-centered radical (NCR) precursors for
C–N bond formation [47–49], we have recently reported a mild alternative for imine formation that
uses iodine and pre-formed iminoiodinane reagents in the presence of light (Scheme 1, method C),
which addresses many of the shortcomings of traditional methods [49]. NCR-mediated reactions
have seen substantial advances recently, due to the advent of visible-light photoredox catalysis and
the development of predictable NCR precursors [50
have utilized NCR species for carbonyl activation [49
–
52], but there have been very few reports that
53 55]. In order to develop an even more
,
–
practical and operationally simple method, we aimed to use commercially available, stable reagents
such as sulfonamide and (diacetoxyiodo)benzene (referred to as PhI(OAc)2 or PIDA) under relatively
mild conditions. Herein we disclose a new pathway to produce N-sulfonyl imines without the
removal of water, using a hypervalent iodine reagent (PIDA) [56], iodine, aldehyde, and sulfonamide,
along with a two-step (one-pot) method to form N-alkylsulfonamides. According to mechanistic
studies, the reaction appears to operate through a unique mechanism that involves a radical initiation
step, followed by a more traditional condensation of the sulfonamide unit.

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Scheme 1. Current methods of N-sulfonyl aldimine formation from aryl aldehydes.
2. Results
We have previously described the formation of N-sulfonyl aldimines, using iminoiodinane
reagents and aryl aldehyde reagents, that is believed to proceed through an N-centered radical (NCR)
pathway (Scheme 2) [49]. During our initial investigation, N,N0-diiodosulfonamide, formed from
iminoiodinane and I2, was isolated and shown to be a likely reactive species in the reaction [49].
0
N,N –Diiodosulfonamide moieties are highly reactive species, in which both of the available N–I bonds
can be activated by ambient light without the need for a transition-metal catalyst, UV photoreactor,
or external chemical initiator. From experimental observations, it was speculated that an NCR species
resulting from N,N0–diiodosulfonamide was serving as a radical initiator and activator of aldehyde,
though a detailed mechanism was unclear at the time. We envisioned the in-situ formation and usage
of acetyl hypoiodite (IOAc) (resulting from the addition of I2 to PhI(OAc)2) [57,58] with a sulfonamide
as a different and more convenient initiator in the formation of N-sulfonyl imines, thus eliminating the
need to synthesize iminoiodinane reagents.
Scheme 2. General reaction for the formation of N-sulfonyl imines from iminoiodinane/I2.
2.1. Optimization of Reaction Conditions and Control Reactions
In our initial attempt to form N-sulfonyl aldimine, 4-bromobenzaldehyde (1) was selected as a
representative aldehyde, and tested using PhI(OAc)2, I2, and a representative sulfonamide (NsNH2)

Molecules 2018, 23, 1838
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following conditions similar to our previously reported iminoiodinane/I2 system (Table 1, entry 1) [49].
To our delight, a 34% yield was obtained using 1 equivalent of PhI(OAc)2, and was improved to 42%
(entry 2) when the amou◦nt of PhI(OAc)2 was increased to 2 equivalents. It was observed that under
ambient temperature (20 C) conditions, product 2de does not form in the absence of either PhI(OAc)2
or I2 (entries 3–5). To determine if the reaction might simply be an acid-mediated condensation of
4-bromobenzaldehyde (1) and Ns–NH2, an experiment using hydroiodic acid (HI) was conducted at
20 ◦C, but as shown in entry 6, no product was observed. This result indicates that the reaction is not
simply proceeding through a traditional acid-promoted, dehydrative condensation pathway of an
aldehyde and sulfonamide at ambient temperature.
Table 1. Optimization and control reactions for the PhI(OAc)2/I2 formation of N-sulfonyl imines.
Equiv.
PhI(OAc)2
Temp
(◦ C)
Time
(h)
Yield
Entry Equiv. 1
Equiv. I2
Light
Additive
2de (%) 1
1
2
3
4
5
6
7
8
9
5
5
5
5
5
5
5
5
2
1
5
5
1
2
0
1
0
0
1
2
2
2
2
2
1
1
1
0
0
0
1
1
1
1
1
1
20
20
20
20
20
20
50
50
50
50
50
50
48
48
48
48
48
48
24
24
24
24
8
White LED
White LED
White LED
White LED
White LED
White LED
Ambient 2
Ambient
Ambient
Ambient
Ambient
Ambient
None
None
None
None
None
0.55 eq HI
None
None
None
None
None
None
2
34
42
0
0
0
0
57
72
8
1
65
59
10
11
12
4
Yields are based upon 1H-NMR integration with 1,4-dimethoxybenzene as internal standard. “Ambient” light
1
means no additional light irradiation was used beyond what is found in an illuminated laboratory setting. Reactions
were conducted in a fume hood with a 30 W fluorescent bulb approximately 1 m overhead.
As shown in Table 1, entry 7, the efficiency of the reaction is improved upon heating to
50 C. In entries 8–10, the stoichiometry of the aldehyde was varied, and interestingly, an excess
of >2 equivalents is necessary to provide 2de in good yield.
◦
Using optimized reaction conditions, a series of additional control experiments were conducted
(Table 2). At 50 ◦C, light appears to be an unnecessary component of the reaction, as shown in entries
1 and 5, in which a similar yield was obtained when compared to the standard reaction (entry 1).
The absence of I2 in the reaction was shown to be detrimental, though formation of 2de did occur
at 50 ◦C, as shown in entry 2. This is in stark contrast to the reaction at 20 ◦C, in which the absence
of I2 resulted in no formation of 2de. Additionally, the reaction is severely affected when activated
molecular sieves are used to remove water during the course of the reaction (entry 4). Finally, the
addition of 1 equivalent of 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO), a known radical inhibitor,
resulted in a substantial decrease in product yield (entry 6), indicating that a radical species might be
present in the mechanistic pathway.

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Table 2. Control reactions for the iminoiodinane/I2 formation of N-sulfonyl imines.
Entry
Variation from Standard Conditions
Yield 2de (%) 1
1
2
3
4
5
6
NONE
0 equiv. I2
0.2 equiv. I2
72
40
66
8
74
19
4A Molecular sieves
Reaction in dark 2
1 equiv. TEMPO
2
Yields are based upon 1H-NMR integration with internal standard. Reaction vessel was wrapped in aluminum
1
foil and the experiment was performed in a laboratory with all lights turned off.
◦
To further investigate the observed difference in reactivity (and dependence upon I2) at 20 and 50 C,
additional experiments were conducted at 30 and 40 ◦C in the presence and absen◦ce of 1 equivalent I2.
The results of these experiments are shown in Table 3. Reactions conducted below 50 C appear to operate
◦
through an iodine-dependent, light-promoted pathway, whereas at 50 C, enough thermal energy may be
available to facilitate the reaction with or without the formation of an N–I bond.
Table 3. Temperature dependence of the PhI(OAc)2-promoted N-sulfonyl imine formation in the
presence (and absence) of I2.
◦
Entry
Oil Bath Temperature ( C)
Eq. I2
Yield 2de (%) 1
1
2
3
4
5
6
7
8
1
20
20
30
30
40
40
50
50
0
1
0
1
0
1
0
1
0
39
0
42
5
72
40
72
Yields are based upon 1H-NMR integration with internal standard.
2.2. Substrate Scope
Most N-sulfonyl imines can be isolated either by crystallization or silica gel chromatography,
though in our past experience, successive recrystallizations may be required in order to remove
the excess aldehyde, thus lowering the isolated yield. For this reason, we have determined the
1
yields of N-sulfonyl imines via H-NMR integration, with an internal standard by focusing upon
the distinctive N-sulfonyl imine C–H proton (Scheme 3) [49]. In order to further verify the formation of
N-sulfonyl imines, we have also developed a two-step (one-pot) reduction of N-sulfonyl imine products,
using excess NaBH4 (Scheme 3). The resulting N-alkylsulfonamides represent an additional important
class of synthetic targets within the drug discovery and development community. In fact, within the

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array of approximately 60 pharmaceuticals marketed in the United States that contain a sulfonamide
group, there are 18 drugs that contain an N-alkylsulfonamide unit as a key molecular feature [59].
Scheme 3. Two-step (one-pot) formation of N-alkylsulfonamides from aldehydes and sulfonamide.
Using the optimized◦ reaction conditions (5 equivalents aldehyde, 2 equivalents PhI(OAc)2,
and 1 equivalent I2 at 50 C and 24 h in chloroform), a survey of the substrate scope with regard
to aldehyde and sulfonamide was investigated (Table 4). In entries 1–13, a range of aldehydes were
varied against a relatively electron-rich sulfonamide, Ts-NH2. The effect of the electronic nature of the
aldehyde was investigated by using a variety of electron-donating and withdrawing substituents. Though a
relatively small preference for an electron-rich aldehyde substrate was observed regarding the formation
of N-sulfonyl imines (entries 1–7), the reaction consistently produced moderate to good yields of imines
(2) and N-alkylsulfonamides (3) (see experimental Supporting Information for spectra). A number of
functionalities are tolerated, including aryl ether, aryl halide, nitro, cyano, and benzylic C–H bonds.
Table 4. Substrate scope of N-sulfonyl imine 2 and N-alkylsulfonamide 3 formation.
Entry
(Aldehyde) R1
(Sulfonamide) R2
Product 2 Yield (%) 1
Product 3 Yield (%) 2
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
4-OCH3
4-CH3
H
4-Br
4-Cl
4-NO2
4-CN
3-CH3
2-CH3
3-OCH3
2-OCH3
3-Br
2-Br
4-CH3
4-Cl
4-CH3
4-CH3
4-CH3
4-CH3
4-CH3
4-CH3
4-CH3
4-CH3
4-CH3
4-CH3
4-CH3
4-CH3
4-CH3
H
2aa 61
2ba 71
2ca 67
2da 54
2ea 65
2fa 50
2ga 52
2ha 70
2ia 60
2ja 60
2ka 65
2la 50
2ma 36
2bb 69
2eb 66
2hb 60
2bc 60
2dc 58
2bd 35
2ae 34
2ee 27
2bf 25
2bg 6
3aa 61
3ba 60
3ca 50
3da 45
3ea 74
3fa 40
3ga 44
3ha 33
3ia 33
3ja 40
3ka 40
3la 22
3ma 30
3bb 40
3eb 70
3hb 38
3bc 40
3dc 54
3bd 17
3ae 11
3ee 21
3bf 8
H
H
4-Cl
4-Cl
2-CH3
4-CH3
4-Br
4-CH3
4-OCH3
4-Cl
2-Cl
4-NO2
4-NO2
3-NO2
2-NO2
4-CH3
4-CH3
1
3bg trace
Yields are based upon 1H-NMR integration with internal standard. Isolated yields.
2

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In Table 4, entries 14–23, a variety of different sulfonamide substrates were tested. Yields relatively
consistent with Ts-NH2 were obtained using sulfonamide substrates, such as 4-Cl-PhSO2NH2 and
PhSO2NH2 (entries 14–18). In reactions that employed less electron-rich sulfonamides, the yields
were negatively impacted (entries 20–23) relative to Ts-NH2. In addition, sulfonamides with ortho
substituents on the aryl ring also performed poorly relative to their para-substituted analogues
(entries 19 and 23). The practicality and operational simplicity of the system offers a complementary
strategy to the use of iminoiodinanes for the introduction of a variety of N-sulfonyl units directly from
commercially available sulfonamides.
2.3. Investigation of Mechanism
To determine the likely mechanistic pathway of the imine-forming transformation, additional
experiments were performed, in an attempt to differentiate between a traditional carbonyl/amine
condensation and a radical-facilitated activation of the aldehyde.
2.3.1. Deuterium-Labeling Experiment
Initially, it was hypothesized that the reaction mechanism would proceed through a pathway
in which an acyl radical is initially formed by abstraction of the aldehydic C–H by a radical initiator,
such as acetyl hypoiodite (IOAc), or an NCR species generated from the sulfonamide. To determine if
the aldehydic C–H was abstracted, a deuterated aldehyde (
precedent, and reacted under the optimized reaction conditions with Ts-NH2 (Scheme 4) [49
Following the two-step reduction procedure with NaBH4, a 58% yield of the N-alkylsulfonamide
product ( ) was isolated, with complete retention of the C–D bond. This result indicates that the C–N
4) was prepared according to literature
,
60].
5
bond-forming step may not involve an acyl radical species, and is much more likely operating through
a traditional nucleophilic condensation of the sulfonamide and aldehyde. However, an acyl radical
species cannot be eliminated from a plausible mechanism, because this result is complicated by the
requirement of an excess of aldehyde substrate in order to obtain an observable amount of product.
Scheme 4. Mechanistic probe experiment using deuterium-labeled aldehyde.
2.3.2. Isolation of Mechanistic Intermediates
In an effort to understand the requirement for an excess of aldehyde substrate, we sought to
determine whether or not additional products may be formed from the aldehyde substrate under
the reaction conditions. Under the optimized reaction conditions for producing N-sulfonyl imines,
no precautions are taken to remove water prior to or during the reaction (in fact, removal of water is
detrimental, as shown in Table 2, entry 4). In addition, a broad peak in the vicinity of a carboxylic acid
O–H proton was observed in several crude reactions when quantifying yields by 1H-NMR. With this in
mind, an experiment was designed to investigate the possible formation of a carboxylic acid byproduct
under standard conditions in the presence of water (Scheme 5). The formation of 4-chlorobenzoic acid
(6) was observed under standard reaction conditions (in the absence of sulfonamide) using 1 equivalent
of aldehyde. This oxidation is likely occurring through abstraction of the aldehydic C–H to form an

Molecules 2018, 23, 1838
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intermediary acyl radical species, via either an IOAc radical initiator or a N-centered radical produced
in situ from an iodinated sulfonamide.
Scheme 5. Conversion of aldehyde to carboxylic acid with H2O under PhI(OAc)2/I2 conditions.
Following this observation, an investigation was conducted regarding the ability of
4-bromobenzoic acid to serve as an acidic agent in the promotion of a sulfonamide/aldehyde
condensation, to form an N-sulfonyl imine. As shown in Scheme 6, the condensation of Ts-NH2
and 4-bromobenzaldehyde is promoted by 4-bromobenzoic acid (albeit with low efficiency), but the
condensation does not occur in the absence of 4-bromobenzoic acid, and interestingly, in the absence
of I2. The condensation is not simply promoted by I2 serving as a Lewis acid either, as shown by the
lack of imine formation in the presence of I2 and the absence of 4-bromobenzoic acid. This implies
that IOAc or I2 could play a role in the activation of both the aldehyde and the sulfonamide. In fact,
the formation of a sulfonamide N–I bond occurs under similar conditions in a number of reported
systems [61–67]. These results further validate the importance of the oxidizing agent PIDA in the
system, but also provide support for the potential role of benzoic acid formed as a byproduct and
potentially important component in the mechanistic pathway of the reaction.
Scheme 6. 4-BrPhCOOH-promoted condensation of aldehyde and sulfonamide.
3. Discussion
3.1. Trends in Reactivity
In our previously reported system, using iminoidinane reagents with I2 at room temperature,
a clear preference was observed for aldehyde substrates with electron-donating groups [49]. In addition,
the most effective iminoiodinane was consistently the electron-deficient PhI = NNs [49]. These trends
are no longer seen in this study when using PIDA/I2 and sulfonamide. A slight preference for
electron-rich aldehydes may be present, but it is not significant (Table 4, entries 1–7). The sulfonamide
species, however, appears to play an important role in the present system. The reaction appears to
be hindered by electron-deficient sulfonamides, or those that contain ortho-substituted aryl rings.
This appears to be more indicative of a traditional role of nucleophilic sulfonamide in a condensation
reaction. With regard to the in-situ reduction to N-alkylsulfonamide species, some reductions may
appear to be more facile than others; however, we believe at this time that the inconsistent conversion
of various N-sulfonyl imines to their respective N-alkylsulfonamide products is simply an artifact of
the isolation of the resulting N-alkylsulfonamides. Some examples required multiple chromatographic
separations of the benzyl alcohol (from reduction of the excess aldehyde substrate) and benzyl amine,
and the relatively lower yields are simply a result of the removal of benzyl alcohol after reduction of
the excess aldehyde.

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3.2. Proposed Mechanism
The plausible mechanism presented in Scheme 7 attempts to account for the following
experimental observations: (1) a decrease in imine production in the presence of either a radical
inhibitor (TEMPO) or molecular sieves; (2) the requirement of PIDA and an excess of >2 equivalents
of aldehyde; (3) the complete retention of the aldehydic C–H (D) in the imine or N-alkylsulfonamide
product; (4) the observed oxidation of an aldehyde to a carboxylic acid using PIDA/I2/H2O; and (5) the
likely involvement of an R–N(I)H species, as indicated by the requirement of I2 in the acid-promoted
condensation in Scheme 5.
Scheme 7. Proposed mechanism of I2-promoted N-sulfonyl formation.
Upon generation of acetyl hypoiodite
produce NCR precursor
. Activated either by visible light (room temperature) or heating at 50 ◦C,
the NCR species forms and facilitates C–H (D) abstraction from a sacrificial equivalent of aldehyde,
to produce a relatively stable acyl radical . This acyl radical species can either combine with or be
oxidized by the iodine radical to form species or , which would readily form the carboxylic acid
in the presence of water. This acid can then aid in a condensation reaction with a second equivalent of
aldehyde, shown as . In order to generate a more nucleophilic sulfonamide species, it is plausible
that a second equivalent of the R-N(I)H species will form from sulfonamide and IOAc, to produce a
more reactive species by attack from iodide (which would in turn regenerate I2). The condensation of
nucleophilic with an aldehyde activated by a carboxylic acid would result in complete retention of
the aldehydic C–H (D) bond, and also produce the water needed for the production of carboxylic acid
. This mechanistic pathway is unconventional in the sense that it involves both a radical activation
step and a traditional nucleophilic condensation step.
A from PIDA and I2, the sulfonamide is iodinated to
B
C
D
E
F
G
H
B
I
I
H
G

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4. Materials and Methods
4.1. Chemicals and Instruments
All reagents and solvents were purchased from commercial sources and used without further
purification. I2 was purchased from Alfa Aesar (Tewksbury, MA, USA) in 99.99+% purity (metals basis).
A description of the construction of our light bath (LED) photochamber is provided in the Supporting
1
Information. H- and 13C-NMR spectra were recorded on a Varian 400/100 (400 MHz) spectrometer
(Agilent Technologies, Palo Alto, CA, USA) in deuterated chloroform (CDCl3), with the solvent
1
residual peak as internal reference unless otherwise stated (CDCl3: H = 7.26 ppm, 13C = 77.23 ppm).
Data are reported in the following order: Chemical shifts (δ) are reported in ppm, and spin–spin
coupling constants (J) are reported in Hz, while multiplicities are abbreviated by s (singlet), d (doublet),
dd (doublet of doublets), t (triplet), dt (double of triplets), td (triplet of doublets), and m (multiplet).
Infrared spectra were recorded on a Nicolet iS50 FT-IR spectrometer (ThermoFisher Scientific, Waltham,
MA, USA), and peaks are reported in reciprocal centimeters (cm−1). Melting points (M.p.) were
recorded on a Mel-Temp II (Laboratory Devices) and were uncorrected. Accurate mass spectrum
(HRMS—High Resolution Mass Spectrometry) was performed using a Thermo Scientific Exactive
spectrometer (Waltham, MA, USA) operating in positive ion electrospray mode (ESI–electrospray
ionization).
4.2. Synthetic Procedures
4.2.1. General Procedure for the Preparation of N-Sulfonyl Imines (2) (1H-NMR Yields)
To an oven-dried reaction tube was added aldehyde (1.25 mmol, 5 equivalents), PhI(OAc)2
(0.50 mmol, 2 equivalents), sulfonamide (0.25 mmol, 1 equivalent), I2 (0.25 mmol, 1 equivalents),
◦
and CDCl3 (3 mL). The mixture was stirred at 50 C under argon for 24 h. After 24 h, the reaction was
cooled to room temperature and an internal standard was added (1,4-dimethoxybenzene, 0.25 mmol,
35 mg); the mixture then was stirred for an additional 5–10 min. The percent yield was calculated
against the internal standard via 1H-NMR integrations of the imine C–H signal and the aromatic (4H)
signal of the internal standard.
4.2.2. General Procedure for the Preparation of N-Alkylsulfonamides (3)
To an oven-dried flask was added aldehyde (2.5 mmol, 5 equivalents), sulfonamide (0.5 mmol,
1 equivalents), PhI(OAc)2 (1.0 mmol, 2 equivalents), I2 (0.5 mmol, 1 equivalent) in CHCl3 (6 mL).
The mixture was stirred at 50 ◦C under argon for 24 h. After 24 h, the reaction was cooled to room
temperature and solvent was removed using a rotary evaporator. The crude was dissolved in 12 mL of
a 1:1 MeOH/DCM mixture, and placed in an ice bath to cool to 0 ◦C. NaBH4 (0.312 g, ~8 mmol) was
added in small portions. After addition, the mixture was removed from the ice bath and stirred at room
temperature for an additional 45 min. After 45 min, the reaction was quenched with 12 mL H2O and
then extracted with EtOAc (2
dried (Na2SO4), and filtered, and the filtrate solvent was removed by evaporation. The resulting crude
N-alkylsulfonamide was purified by silica gel flash chromatography, using a hexanes:EtOAc eluent.
×
20 mL). The combined organic layers were washed with brine (20 mL),
3
4.2.3. Isotopically Labeled Experiment
Deuterated aldehyde was prepared according to a known procedure from ester reduction with
LiAlD4, followed by Dess–Martin oxidation to the aldehyde [49 60]. To an oven-dried reaction tube was
4
,
added the deuterated aldehyde (0.625 mmol, 0.074 mL), p-toluenesulfonamide (0.125 mmol, 0.0214 g),
iodobenzene diacetate (0.250◦mmol, 0.0805 g), and I2 (0.125 mmol, 0.0317 g), all in CHCl3 (1.5 mL).
The mixture was stirred at 50 C under argon for 24 h in a white LED chamber. After 24 h, the solvent
was evaporated, and CDCl3 was added to record a 1H-NMR of the crude mixture. The title compound
5
was isolated from this crude mixture with a 58% yield following the general procedure for preparation

Molecules 2018, 23, 1838
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◦
of N-alkylsulfonamides: white solid (20 mg, 58%).; m.p. 86–88 C; purification (hexanes:EtOAc, 70:30);
Rf = 0.59; 1H-NMR (400 MHz, CDCl3)
= 7.76 (d, J = 8.0 Hz, 2H), 7.31 (d, J = 8.0 Hz, 2H), 7.08 (s, 4H),
4.64 (d, J = 4.0 Hz, 1H), 4.05 (d, J = 4.0 Hz, 1H), 2.44 (s, 3H), and 2.31 (s, 3H) ppm; 13C-NMR (100 MHz,
δ
CDCl3); δ 143.5, 137.7, 136.8, 133.1, 129.7, 129.3, 127.9, 127.2, 46.8, 21.5, and 21.1 ppm; IR (neat) with
ν = 3262, 2923, 1597, 1320, 1152, 1092, 726, and 665 cm−1. HRMS (ESI) calculated for C15H17N1O2S1D1
[M + H]+ requires m/z 277.11365, and m/z 277.11075 was found.
4.2.4. Observation of Carboxylic Acid Intermediate
To an oven-dried round bottom flask was added 4-chlorobenzaldehyde (1 equivalent, 1 mmol),
iodobenzene diacetate (2 equivalent, 2 mmol), I2 (1 equivalent, 1 mmol), H2O (2 equivale◦nt, 2 mmol)
in CHCl3 (12 mL). A reflux condenser was attached and the reaction was stirred at 50 C for 24 h.
After the reaction time, 7 mL of 1 M NaOH solution was added to the reaction mixture. The aqueous
portion was then separated and acidified using 4 mL of a 15% HCl solution. Compound
6 was then
extracted with EtOAc (3 7 mL). The combined organic layers were dried with Na2SO4 and the
×
solvent evaporated. Characterization of 6 was made in comparison to known spectral data.
4.2.5. Carboxylic Acid-Promoted Condensation
To an oven-dried reaction tube was added 4-bromobenzoic acid (1 equivalent, 0.125 mmol),
4-bromobenzaldehyde (2 equivalents, 0.25 mmol), p-toluenesulfonamide (1 equivalent, 0◦.125 mmol),
and I2 (1 equivalent, 0.125 mmol) in 1.5 mL of CDCl3. The reaction was stirred at 50 C for 24 h.
The reaction was then cooled to room temperature, an internal standard (1,4-dimethoxybenzene) was
added, and the reaction mixture was directly analyzed by 1H-NMR.
4.3. Characterization Data
1
Characterization via H-NMR of all intermediate N-sulfonyl imines was accomplished using
comparisons to reported spectra, and an additional table of imine C–H peaks is included in the ESI.
All N-alkylsulfonamides were isolated according to general procedure. Products 3aa
[
68], 3ae
[
[
69],
75],
3ba
3ja
[
68], 3bb
[
70], 3bf
[
71], 3ca
[68], 3da [72], 3ea [68], 3eb [70], 3ee [69], 3ha [73], 3hb [74], 3ia
[
73], 3ka
[73], 3la
[72], and 3ma
[
72] have been reported, and the characterizational data was
in agreement with literature values (spectra and full characterization available in ESI). Additional
N-alkylsulfonamides display the characterizational data shown below.
4.3.1. 4-Chloro-N-[(4-methylphenyl)methyl]-benzenesulfonamide (3bc)
◦
This was prepared according to the general procedure: white solid (59 mg, 40%); M.p. 120–122 C;
purification (hexanes:EtOAc, 70:30); Rf = 0.58; 1H-NMR (400 MHz, CDCl3)
δ
= 7.77 (d, J = 8.0 Hz, 2H),
7.45 (d, J = 8.0 Hz, 2H), 7.06 (m, 4H), 4.86 (t, J = 4.0 Hz, 1H), 4.10 (d, J = 4.0Hz, 2H), and 2.31 (s, 3H) ppm;
13C-NMR (100 MHz, CDCl3)
= 139.1, 138.5, 137.9, 132.8, 129.4, 129.3, 128.6, 127.8, 47.1, and 21.1 ppm;
IR (neat) with
δ
ν
= 3245, 2923, 1586, 1325, 1158, 1092, 1058, 757, and 565 cm−1. HRMS (ESI) calculated
for C14H15N1O2S1Cl1 [M + H]+ requires m/z 296.05120, and m/z 296.05029 was found.
4.3.2. 2-Chloro-N-[(4-methylphenyl)methyl]-benzenesulfonamide (3bd)
This was prepared according to the general procedure: white solid (25 mg, 17%); M.p. 64–66 ◦C;
purification (hexanes:EtOAc, 70:30); Rf = 0.53; 1H-NMR (400 MHz, CDCl3)
δ = 8.09 (d, J = 8.0 Hz, 1H),
7.50–7.49 (m, 2H), 7.42–7.38 (m, 1H), 7.06 (s, 4H), 5.21 (t, J = 4.0 Hz, 1H), 4.07 (d, J = 4.0 Hz, 2H), and
2.29 (s, 3H) ppm; 13C-NMR (100 MHz, CDCl3)
127.9, 127.2, 47.3, and 21.1 ppm; IR (neat) with
δ
137.8, 137.1, 133.6, 132.6, 131.5, 131.4, 131.3, 129.3,
= 3277, 3094, 2924, 1426, 1327, 1163, 1042, 760, and
ν
585 cm−1. HRMS (ESI) calculated for C14H15N1O2S1Cl1 [M + H]+ requires m/z 296.05120, and m/z
296.05140 was found.

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4.3.3. N-[(4-Bromophenyl)methyl]-4-chlorobenzenesulfonamide (3dc)
This was prepared according to the general procedure on a 0.125 mmol scale: white solid (25 mg,
54%); M.p. 126–128 ◦C; purification (hexanes:EtOAc, 70:30); Rf = 0.64; 1H-NMR (400 MHz, CDCl3)
δ = 7.77 (d, J = 8.0 Hz, 2H), 7.48 (d, J = 8.0 Hz, 2H), 7.41 (d, J = 8.0 Hz, 2H), 7.08 (d, J = 8.0 Hz, 2H),
4.82 (t, J = 4.0 Hz, 1H), and 4.11 (d, J = 4.0 Hz, 2H) ppm; 13C-NMR (100 MHz, CDCl3)
δ
139.4, 138.3,
135.0, 131.8, 129.50, 129.45, 128.5, 122.0, and 46.6 ppm; IR (neat) with
ν = 3246, 3087, 1573, 1320, 1153,
826 cm−1; HRMS (ESI) calculated for C13H12N1O2S1Cl1Br1 [M + H]+ requires m/z 361.94607, and m/z
361.94302 was found.
4.3.4. 4-Methyl-N-[(4-nitrophenyl)methyl]-benzenesulfonamide (3fa)
◦
This was prepared according to the general procedure: yellow solid (62 mg, 40%); M.p. 111–113 C;
purification (hexanes:EtOAc, 60:40); Rf = 0.47. H-NMR (400 MHz, CDCl3)
1
δ = 8.12 (d, J = 8.0 Hz,
2H), 7.74 (d, J = 8.0 Hz, 2H), 7.40 (d, J = 8.0 Hz, 2H), 7.30 (d, J = 8.0 Hz, 2H), 5.13 (t, J = 4.0 Hz, 1H),
4.24 (d, J = 4.0 Hz, 2H), and 2.44 (s, 3H) ppm. 13C-NMR (100 MHz, CDCl3)
δ
144.0, 143.9, 136.6, 129.9,
128.4, 127.1, 128.8, 46.4, 27.5, and 21.6 ppm; IR (neat) with
ν = 3252, 2855, 1516, 1309, 1150, 1109,
and 814 cm−1. HRMS (ESI) calculated for C14H15N2O4S1 [M + H]+ requires m/z 307.07525, and m/z
307.07452 was found.
4.3.5. N-[(4-Cyanophenyl)methyl]-4-methylbenzenesulfonamide (3ga)
◦
This was prepared according to the general procedure: white solid (63 mg, 44%); M.p. 120–126 C;
purification (hexanes:EtOAc, 60:40); Rf = 0.38. H-NMR (400 MHz, CDCl3)
1
δ = 7.72 (d, J = 8.0 Hz,
2H), 7.53 (d, J = 8.0 Hz, 2H), 7.35 (d, J = 8.0 Hz, 2H), 7.29 (d, J = 8.0 Hz, 2H), 5.43 (t, J = 4.0 Hz, 1H),
4.17 (d, J = 4.0 Hz, 2H), and 2.44 (s, 3H) ppm; 13C-NMR (100 MHz, CDCl3) δ 143.9, 142.0, 136.6, 132.3,
129.8, 128.3, 127.0, 118.5, 111.5, 46.6, and 21.5 ppm; IR (neat) with
ν = 3234, 2922, 2857, 2230, 1594, 1324,
1152, 1069, 842, 815, and 548 cm−1. HRMS (ESI) calculated for C15H15N2O2S1 [M + H]+ requires m/z
287.08543, and m/z 287.08475 was found.
5. Conclusions
A relatively mild and operationally simple transformation of aldehydes to N-sulfonyl imines
using commercially available reagents has been described. At room temperature, the reaction is
promoted by visible light and does not require removal of water. A variety of N-sulfonyl aldimines and
benzylic N-alkylsulfonamides (resulting from a two-step, one-pot reduction) have been prepared from
a range of aryl aldehydes and sulfonamides with moderate to good yields. A mechanistic investigation
has provided evidence for a radical-initiated activation of a sacrificial equivalent of aldehyde, in order
to produce a carboxylic acid in the presence of water, which in turn facilitates a condensation reaction
between an activated sulfonamide and a second equivalent of aldehyde. Further investigation of
analogous functional groups and reacting N-species is currently underway.
Supplementary Materials: Supplementary materials including spectral characterization are available online.
Author Contributions: Conceptualization, A.A.L.; Methodology, M.D.H. and A.A.L.; Investigation, M.D.H.,
Z.C.B., A.J.H.; Data Curation, M.D.H. and A.A.L.; Validation and Formal Analysis, M.D.H., Z.C.B., A.J.H., and
A.A.L.; Writing-Original Draft Preparation, A.A.L.; Writing-Review & Editing, A.A.L.; Supervision, A.A.L.; Project
Administration, A.A.L.; Funding Acquisition, A.A.L. and M.D.H.
Funding: The research results discussed in this publication were made possible in part by funding through the
award for project number HR18-013, from the Oklahoma Center for the Advancement of Science and Technology
(OCAST). We are also grateful for the financial support provided by the lab start-up contribution from The
University of Tulsa. We would also like to thank the Office of Research and Sponsored Programs for M.D.H.’s
Student Research Grant, as well as the Tulsa Undergraduate Research Challenge (TURC) and Chemistry Summer
Undergraduate Research Program (CSURP) for support.
Acknowledgments: We acknowledge Kenneth P. Roberts, The University of Tulsa, for his assistance with obtaining
MS data. Additionally, we would like to acknowledge Syed R. Hussaini, The University of Tulsa, for helpful
suggestions regarding the two-step isolation method.

Molecules 2018, 23, 1838
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Conflicts of Interest: The authors declare no conflict of interest.
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δ
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Sample Availability: Samples of the N-alkylsulfonamide compounds (3aa–3bf; Table 4) are available from
the authors.
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