Stereoselective Total Synthesis of (-)-Picrotoxnin and (-)-Picrotin

DOI: 10.1021/ja00192a035

Source and publish data:

Journal of the American Chemical Society p. 3728 - 3734 (1989)

Update date:2022-08-03

Topics: Asymmetric synthesis NMR spectroscopy Total synthesis Aldehyde Stereoselective Diastereoselective Organocatalysis Chiral Auxiliary

Authors:

Miyashita, Masaaki

Suzuki, Toshio

Yoshikoshi, Akira

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Article abstract of DOI:10.1021/ja00192a035

The stereoselective total synthesis of (-)-picritoxnin (1) and (-)-picrotin (2), starting from (+)-5β-hydroxycarvone (3), is described.Eight contiguous asymmetric centers on a cis-fused hydrindane ring system were stereoselectively prepared via three key

Full text of DOI:10.1021/ja00192a035

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