Microwave-assisted synthesis of fused tricyclic pyrazino[1,2-a]indole derivatives

Article abstract of DOI:10.1007/s00706-014-1216-7

A microwave-assisted expedient route for the synthesis of novel 3-phenylpyrazino[1,2-a]indol-1(2H)-one derivatives is reported. The method has advantages such as accelerated reaction rate, excellent yields, simplicity of operation, and is eco-friendly. Microwave heating of ammonium acetate generates the NH₃ nucleophile required for the cyclization reaction and acetic acid. Graphical abstract: [Figure not available: see fulltext.]