SYNTHESIS OF (+)-DISPARLURE USING THE REACTION OF 6-METHYLHEPTYL PHENYL SULPHONE WITH TRIMETHYLSILYL ETHYLENE OXIDE AND ASYMMETRIC EPOXIDATION

Article abstract of DOI:10.1016/S0040-4039(00)99140-8

Lithiated sulphone 2 was reacted with trimethyl(oxiranyl)silane 3 to yield allylic alcohol 4; the latter was epoxidized by the Sharpless procedure and the corresponding hydroxy-epoxide 5b was transformed into (+)-disparlure 6 via tosylate 5c.