Journal of Organic Chemistry p. 2746 - 2748 (1984)
Update date:2022-08-04
Topics:
Barbachyn, Michael R.
Johnson, Carl R.
Glick, Milton D.
The total synthesis of (-)-rothrockene, trans-1-(1-methylethenyl)-2-(2-methyl-1-propenyl)cyclopropane, and its enantiomer is described.Utilization of (-)-(R)-N,S-dimethyl-S-phenylsulfoximine in the synthesis allowed for resolution of a precursor, regio- and diastereoface selectivity in a Simmons-Smith cyclopropanation, determination of absolute configuration based on X-ray crystallography, and introduction of a side-chain double bond.The absolute configuration of the natural substance is shown to be 1R,2S.
View MoreContact:+86-0512-88957371
Address:shanghai
Contact:+86-10-62651721
Address:29 Yongxing Road, Daxing District,Beijing China
Contact:+86-579-85206992
Address:No 451 chouzhou north road ,room 1106 int'l business center , yiwu ,china
Zhejiang kehong chemical co., ltd
Contact:0086-575-85522000
Address:xiner center RD binhai industrial zone shaoxing zhejiang province P.R.China,312073
Contact:18698110882
Address:1303 No2 building,LuoMa Garden,YongAn Road,Hexi District,Tianjin city
Doi:10.1021/om034253n
(2004)Doi:10.1016/0022-328X(84)85014-7
(1984)Doi:10.1016/j.tetasy.2012.06.013
(2012)Doi:10.1016/j.jorganchem.2013.02.024
(2013)Doi:10.1021/acs.jmedchem.6b01196
(2017)Doi:10.1002/ejic.200500182
(2005)
