SYNTHESIS OF ENANTIOMERICALLY ENRICHED ATROLACTIC ACID AND OTHER α-HYDROXY ACIDS

DOI: 10.1016/S0040-4039(01)82109-2

Source and publish data:

Tetrahedron Letters p. 4221 - 4224 (1981)

Update date:2022-08-04

Topics:

Authors:

Frater, Gy.

Mueller, U.

Guenther, W.

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Article abstract of DOI:10.1016/S0040-4039(01)82109-2

The α-anions of 2-substituted 1,3-dioxolan-4-ones derived from chiral mandelic and lattic acid (2a, 2b; 3a; 10a, 10b) were alkylated with high stereoselectivity, The products formed were hydrolysed to α-hydroxy acids with 65-85percent e.e. ((S)(+)-5,7,9, (R)(-)-13).

Full text of DOI:10.1016/S0040-4039(01)82109-2

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