Structure-based discovery of glycolipids for CD1d-mediated NKT cell activation: Tuning the adjuvant versus immunosuppression activity

DOI: 10.1021/ja062740z

Source and publish data:

Journal of the American Chemical Society p. 9022 - 9023 (2006)

Update date:2022-08-05

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Authors:

Fujio, Masakazu

Wu, Douglass

Garcia-Navarro, Raquel

Ho, David D.

Tsuji, Moriya

Wong, Chi-Huey

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Article abstract of DOI:10.1021/ja062740z

Introduction of an aromatic group into the fatty acyl chain of α-GalCer modulates the activity and selectivity of IFN-γ/IL-4 secretion through CD1d-mediated activation of NKT cells. Compound 14-16 are more potent than α-Galcer and biased for IFN-γ than fo

Full text of DOI:10.1021/ja062740z

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