Regiospecific Synthesis of Aromatic Compounds via Organometallic Intermediates. 4. Synthesis of Ortho-Disubstituted Benzenes

Article abstract of DOI:10.1021/jo00189a028

Phthalides 1 and phthalans 2 with substituents in the heterocyclic ring have been prepared starting from o-dibromobenzene via sequential metal-halogen exchange reactions and treatment with appropriate electrophiles.Low temperatures are essential for the s