Synthesis of the C1-phosphonate analog of UDP-GlcNAc

DOI: 10.1016/j.carres.2006.05.008

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Carbohydrate Research p. 1998 - 2004 (2006)

Update date:2022-08-04

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Authors:

Chang, Robert

Vo, Thanh-Trang

Finney, Nathaniel S.

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Article abstract of DOI:10.1016/j.carres.2006.05.008

We describe the first synthesis of the C1-phosphonate analog of UDP-GlcNAc, based on a new preparation of the corresponding glycosyl phosphonate. This C-glycosyl analog is shown to be a very weak inhibitor (K_i > 10 mM) of fungal chitin synthase

Full text of DOI:10.1016/j.carres.2006.05.008

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