Organic & Biomolecular Chemistry
Paper
column chromatography (PE/EtOAc) to afford pure products
3a–3u.
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General procedure for the synthesis of 2,3-diaryl indoles 5a–5h
A nitrogen-filled round-bottom flask was charged with 1a
(100 mg, 0.47 mmol), Pd(PPh3)4 (54 mg, 0.047 mmol) and
anhydrous DMF (3 mL), and then Et3N (0.13 mL, 0.94 mmol)
and PhI (96 mg, 52 µL, 0.47 mmol) were added in order. After
the solution was stirred at 50 °C for 9 h, another portion of
Et3N (0.2 mL, 1.41 mmol) and second aryl iodide (2.35 mmol)
were added to the reaction mixture. After the solution was
stirred at 70 °C for another 24 h, the reaction was quenched
with water, and the aqueous layer was extracted with DCM.
The combined organic layer was dried over MgSO, the volatile
component was removed under vacuum, and then the crude
product was purified by column chromatography (PE/EtOAc)
using silica gel to afford pure products 5a–5h.
Conflicts of interest
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2875–2911; (b) M. Shiri, Chem. Rev., 2012, 112, 3508–3549;
(c) R. Chinchilla and C. Najera, Chem. Rev., 2014, 114,
1783–1826; (d) S. W. Youn and T. Y. Ko, Asian J. Org. Chem.,
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There are no conflicts to declare.
Acknowledgements
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Financial support from the National Natural Science
Foundation of China (21671066, 21673077, 21972045, and
22071055) is greatly acknowledged.
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