Total Chemical Synthesis and Antitumor Evaluation of 4-Demethoxy-10,10-dimethyldaunomycin

DOI: 10.1021/jm00376a021

Source and publish data:

Journal of Medicinal Chemistry p. 1343 - 1347 (1984)

Update date:2022-08-03

Topics:

Authors:

Alexander, Jose

Khanna, Ish

Lednicer, Daniel

Mitscher, Lester A.

Veysoglu, Tarik

et al. et al.

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Article abstract of DOI:10.1021/jm00376a021

The novel anthracycline analogue 4-demethoxy-10,10-dimethyldaunomycin was prepared in nine chemical steps from 5,8-dimethoxy-2-tetralone. It proved to be inactive as an antitumor agent in the mouse P388 lymphocytic leukemia model.

Full text of DOI:10.1021/jm00376a021

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