Conformationally Restrained Fentanyl Analogues. 2. Synthesis and Analgetic Evaluation of Perhydro-1,6-naphthyridin-2-ones

DOI: 10.1021/jm00376a007

Source and publish data:

Journal of Medicinal Chemistry p. 1271 - 1275 (1984)

Update date:2022-08-04

Topics:

Authors:

Borne, Ronald F.

Fifer, E. Kim

Waters, I.W.

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Article abstract of DOI:10.1021/jm00376a007

Conformational flexibility of the N-acyl portion of fentanyl-type analgetics was restricted through the synthesis of novel perhydro-1,6-naphthyridin-2-one derivatives.Neither the cis-fused derivative (5a), the trans-fused derivative (5b), nor the enamide

Full text of DOI:10.1021/jm00376a007

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