Preparation and reactions of functionalized organocopper reagents

Article abstract of DOI:10.1055/s-2006-942496

Functionalized organocopper reagents have been prepared via an iodine-copper exchange by the reaction of aryl or alkenyl iodides with a sterically hindered cuprate reagent, lithium dineophylcuprate [(Me ₂PhCCH₂)₂CuLi]. The resulting copper reagents react readily with various electrophiles leading to polyfunctionalized molecules. This method represents a unique protocol for the preparation of aryl-, heteroaryl- and alkenylcopper reagents. Georg Thieme Verlag Stuttgart.