The Application of N-Substituted Trichloroacetamides as in situ Isocyanate Generating Reagents for the Synthesis of Acylureas and Sulfonylureas

Article abstract of DOI:10.1055/s-1987-28067

In dimethylsulfoxide solution in the presence of excess of powdered sodium hydroxide, N-substituted trichloroacetamides 1 are used as in situ isocyanate generating reagents which can react with carboxamides or sulfonamides 2 to afford acylureas or sulfonylureas 3.