Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: Function of alkyl chain length on opioid activity

DOI: 10.1016/j.bmcl.2006.08.079

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 5793 - 5796 (2006)

Update date:2022-07-30

Topics:

Authors:

Shiotani, Kimitaka

Li, Tingyou

Miyazaki, Anna

Tsuda, Yuko

Bryant, Sharon D.

Ambo, Akihiro

Sasaki, Yusuke

Lazarus, Lawrence H.

Okada, Yoshio

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Article abstract of DOI:10.1016/j.bmcl.2006.08.079

Dimeric opioid analogues linked to a pyrazinone platform, 3-[Tyr/Dmt-NH(CH₂)_m]-6-[Tyr/Dmt-NH(CH₂)_n]-2(1H)-pyrazinone (m, n = 3 or 4), were synthesized. The Tyr-containing compound (m = 4, n = 3) exhibited μ-rece

Full text of DOI:10.1016/j.bmcl.2006.08.079

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