Journal of Medicinal Chemistry p. 1565 - 1570 (1984)
Update date:2022-09-26
Topics:
Maxwell, James R.
Wasdahl, Dan A.
Wolfson, Alan C.
Stenberg, Virgil I.
A series of 5-aryl-2H-tetrazoles, 5-aryl-2H-tetrazole-2-acetic acids, and <(4-phenyl-5-aryl-4H-1,2,4-triazol-3-yl)thio>acetic acids were synthesized and tested in vitro for superoxide scavenging activity, in vivo in the carrageenan-induced rat paw edema assay, and in the reverse passive Arthus reaction.The hydroxy-substituted compounds were effective as in vitro scavengers of superoxide but were not effective as in vivo antiinflammatory agents.
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