Journal of Organic Chemistry p. 4362 - 4369 (2008)
Update date:2022-09-26
Topics:
Patterson, Andrew W.
Peltier, Hillary M.
Ellman, Jonathan A.
(Chemical Equation Presented) An optimized and highly efficient synthesis of potent, bioactive N-methyl tubulysin analogues 2 and 4 has been achieved with > 40% overall yields. This synthesis represents a significant improvement over previously reported s
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