921927-98-2

Upstream product

• 921927-86-8 (2S,4R)-2-Methyl-4-((R)-2-methyl-propane-2-sulfinylamino)-5-phenyl-pentanoic acid methyl ester 
• 921927-89-1 methyl 2-((R,E)-3-(((S)-tert-butylsulfinyl)imino)-1-hydroxy-4-methylpentyl)thiazole-4-carboxylate 
• 921927-90-4 methyl 2-((1R,3R)-3-((S)-1,1-dimethylethylsulfinamido)-1-hydroxy-4-methylpentyl)thiazole-4-carboxylate 
• 921927-93-7 methyl 2-((1R,3R)-3-((2S,3S)-2-azido-3-methylpentanamido)-1-hydroxy-4-methylpentyl)thiazole-4-carboxylate 
• 921927-91-5 methyl 2-((1R,3R)-3-amino-1-hydroxy-4-methylpentyl)thiazole-4-carboxylate hydrochloride 
• 921927-94-8 methyl 2-{(1R,3R)-3-{[(2S,3S)-2-azido-3-methylpentanoyl]amino}-4-methyl-1-[(triethylsilyl)oxy]pentyl}-1,3-thiazole-4-carboxylate 
• 921927-95-9 L-azidoisoleucinyl-N-[(3-methylbutanoyloxy)methyl]-(O-triethylsilyl)-tubuvaline methyl ester 
• 921927-96-0 N-methyl-D-pipecolinyl-L-isoleucinyl-N-[(3-methylbutanoyloxy)methyl]-tubuvaline methyl ester 
• 921927-97-1 N-methyl-D-pipecolinyl-L-isoleucinyl-N-[(3-methylbutanoyloxy)methyl]-tubuvaline 
• 921928-04-3 N-methyl-D-pipecolinyl-L-isoleucinyl-N-[(3-methylbutanoyloxy)methyl]-(O-triethylsilyl)-tubuvaline methyl ester 
• 73956-16-8 ethyl 2-(diethoxymethyl)-1,3-thiazole-4-carboxylate 
• 921927-99-3 methyl 2-(dimethoxymethyl)-4-thiazolecarboxylate 
• 221375-48-0 (N(E),R)-2-methyl-N-(2-phenylethylidene)-2-propanesulfinamide 
• 41447-17-0 (R)-1-methylpiperidine-2-carboxylic acid 

Downstream Products

• 1259372-17-2 cyclo-tubulysin D 

Relevant academic research and scientific papers

Expedient synthesis of N-methyl tubulysin analogues with high cytotoxicity

(Chemical Equation Presented) An optimized and highly efficient synthesis of potent, bioactive N-methyl tubulysin analogues 2 and 4 has been achieved with > 40% overall yields. This synthesis represents a significant improvement over previously reported s

Total syntheses of tubulysins

The total syntheses of tetrapeptides tubulysins D (1b), U (1c), and V (1d), which are potent tubulin polymerization inhibitors, are described. The synthesis of Tuv (2), an unusual amino acid constituent of tubulysins, includes an 1,3-dipolar cycloaddition

The total synthesis of tubulysin D

The first total synthesis of tubulysin D is reported. The development and application of new tert-butanesulfinamide methods allowed for rapid syntheses of the tubuvaline and tubuphenylalanine fragments. Most significantly, a route was devised and implemen