Tyrphostins IV - Highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines

DOI: 10.1016/0968-0896(96)00107-1

Source and publish data:

Bioorganic and Medicinal Chemistry p. 1203 - 1207 (1996)

Update date:2022-08-03

Topics:

Authors:

Gazit, Aviv

Chen, Jeffrey

Harald, App

McMahon, Gerald

Hirth, Peter

Chen, Irit

Levitzki, Alexander

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Article abstract of DOI:10.1016/0968-0896(96)00107-1

Potent 4-anilido-substituted quinazolines which potently inhibit epidermal growth factor receptor (EGFR) kinase were prepared. Structure-activity relationship studies reveal high sensitivity to substitution at the aniline ring.

Full text of DOI:10.1016/0968-0896(96)00107-1

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