Tyrphostins IV - Highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines

DOI: 10.1016/0968-0896(96)00107-1

Source and publish data:

Bioorganic and Medicinal Chemistry p. 1203 - 1207 (1996)

Update date:2022-08-03

Topics:

Authors:

Gazit, Aviv

Chen, Jeffrey

Harald, App

McMahon, Gerald

Hirth, Peter

Chen, Irit

Levitzki, Alexander

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0968-0896(96)00107-1

Potent 4-anilido-substituted quinazolines which potently inhibit epidermal growth factor receptor (EGFR) kinase were prepared. Structure-activity relationship studies reveal high sensitivity to substitution at the aniline ring.

Full text of DOI:10.1016/0968-0896(96)00107-1

Products guided by the article

Product name:4-Quinazolinamine, 6-methyl-N-phenyl-

Cas No:92554-57-9

R&D Labs maybe for 92554-57-9

Weifang Arylchem Chemical Co., LTD

Contact:86-536-5217866

Address:Development Zone, Shouguang, Shandong Province
JinTan Pingsheng Chemical Co.,Ltd

Contact:+86-519-82828200

Address:NO.11Danfengxilu Road,Jintan City,Jiangsu,China
HANGZHOU ZHONGCHANG SCIENTIFIC CO.,LTD

Contact:+86-571-88932183

Address:Hangzhou
Laohekou Jinghong Chemical Co.,Ltd

Contact:+86-0710-3702747

Address:163.East，Huagong Road，Laohekou
ChangZhou Mascotchem. Co.,Ltd.

website:http://www.mascotchem.com

Contact:86-519-85010339

Address:B-802,XingBei Building,391#,Tongjiang Middle Road New District,Changzhou,JS,China

Relevant to this article

Doi:10.1021/ja01868a001
(1940)
Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase

Doi:10.1016/j.bmcl.2005.08.114
(2006)
Expeditious and practical synthesis of tertiary alcohols from esters enabled by highly polarized organometallic compounds under aerobic conditions in Deep Eutectic Solvents or bulk water

Doi:10.1016/j.tet.2020.131898
(2021)
PHOTOCHEMICAL REACTION OF 2-ALKENOYL-1,4-QUINONES. FORMATION OF CHROMONE DERIVATIVES

Doi:10.1246/cl.1985.595
(1985)
Synthesis of DMJ analogs with seven- and eight-membered iminocyclitols

Doi:10.1016/j.tet.2006.12.002
(2007)
Doi:10.1021/jo01101a022
(1958)

Article Doi