The synthesis of a geminally perfluoro-tert-butylated β-amino acid and its protected forms as a potential pharmacokinetic modulator and reporter for peptide-based pharmaceuticals

DOI: 10.1021/jo0616308

Source and publish data:

Journal of Organic Chemistry p. 1464 - 1467 (2007)

Update date:2022-08-04

Topics:

Authors:

Jiang, Zhong-Xing

Yu, Y. Bruce

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Article abstract of DOI:10.1021/jo0616308

(Chemical Equation Presented) To modulate and report the pharmacokinetics of peptide-based pharmaceuticals, a novel geminally perfluoro-tert-butylated β-amino acid (βFa) and its Fmoc- and Boc-protected forms were designed and synthesized. βFa was incorpor

Full text of DOI:10.1021/jo0616308

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