Bioorganic and Medicinal Chemistry Letters p. 964 - 968 (2007)
Update date:2022-08-04
Topics:
Lienard, Benoit M.R.
Horsfall, Louise E.
Galleni, Moreno
Frere, Jean-Marie
Schofield, Christopher J.
Metallo-β-lactamases (MBLs) catalyze the hydrolysis of β-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a Ki of 6.1 ± 0.7 μM against the FEZ-1 MBL but does not significantly inhibit the IMP-1, BcII, CphA or L1 MBLs.
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