Chiral Lewis acid catalysis in aqueous media. Catalytic asymmetric aldol reactions of silyl enol ethers with aldehydes in a protic solvent including water

Article abstract of DOI:10.1246/cl.1999.71

Chiral copper(II)-catalyzed asymmetric aldol reactions of silyl enol ethers with aldehydes have been successfully carried out in a water-ethanol solution. The use of the protic solvent including water is essential in these reactions, and this report has proposed and demonstrated a new concept for solvents in catalytic asymmetric aldol reactions.