Synthesis and structure-activity relationships of tyrosine-based inhibitors of autotaxin (ATX)

DOI: 10.1016/j.bmcl.2010.09.030

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 7132 - 7136 (2010)

Update date:2022-07-31

Topics:

Authors:

East, James E.

Kennedy, Andrew J.

Tomsig, Jose L.

De Leon, Alexandra R.

Lynch, Kevin R.

MacDonald, Timothy L.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.bmcl.2010.09.030

Autotaxin (ATX) is a secreted soluble enzyme that generates lysophosphatidic acid (LPA) through its lysophospholipase D activity. Because of LPA's role in neoplastic diseases, ATX is an attractive therapeutic target due to its involvement in LPA biosynthe

Full text of DOI:10.1016/j.bmcl.2010.09.030

Products guided by the article

Product name:dimethyl (3S)-2-hydroxy-3-palmitamido-4-(4-((4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)phenyl)butylphosphonate

Cas No:935548-52-0

R&D Labs maybe for 935548-52-0

Suzhou Wedo Chemicals Co., Ltd.

Contact:86 512 58100425

Address:Zonger Road, DongSha Industry Park , Zhangjiagang, Jiangsu, China
Henan PURUI Pharmaceutical Co., Ltd.

website:http://www.puruipharm.com

Contact:17739583555

Address:Yezhuangqiao,Xihua town, Henan province
Hangzhou yi lu biont technology Co., LTD

Contact:+86-571-88152630

Address:Hangzhoushi HuafengRoad Yicheng3Building1001room.
AUSHUN PHARMACEUTICAL TECHNOLOGY CO,.LTD

Contact:+86-25-86883560 15951806178

Address:14 Dayingbi, Zhujiang Rd. East, Nanjing, Jiangsu, China.
Binzhou Holly Pharmaceutical Co.,Ltd.

Contact:74517

Address:No.15 Dapu Road,Huangpu District Shanghai,P.R.China

Relevant to this article

New phosphonate reagents for aldehyde homologation

Doi:10.1080/00397910701569114
(2007)
Factors favoring efficient bifunctional catalysis. Study of a ruthenium(II) hydrogenation catalyst containing an N-heterocyclic carbene with a primary amine donor

Doi:10.1021/om300108p
(2012)
Synthesis and X-Ray Crystal Structure of Germaimines

Doi:10.1039/c39910001123
(1991)
Selective recognition of cysteine in its free and protein-bound states by the Zn²⁺ complex of a triazole-based calix[4]arene conjugate

Doi:10.1002/chem.201102791
(2011)
Reactions of a Cyclic Rhodium Carbenoid with Aromatic Compounds and Vinyl Ethers

Doi:10.1021/jo00112a036
(1995)
Synthesis of Allosamidin

Doi:10.1039/c39910001099
(1991)

Article Doi