Fluorine-Containing Amino Acids and Their Derivatives. 4. Synthesis and Antibacterial Activity of Threo and Erythro 1-Fluorodehydroxylated Chloramphenicol Analogues

DOI: 10.1021/jm00380a019

Source and publish data:

Journal of Medicinal Chemistry p. 253 - 256 (1985)

Update date:2022-08-06

Topics:

Authors:

Tsushima, Tadahiko

Kawada, Kenji

Tsuji, Teruji

Tawara, Katsuya

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00380a019

Both threo and erythro 1-fluorodehydroxylated chloramphenicol analogues were synthesized and tested for antimicrobial activity.None showed antibacterial or antifungal activity, clearly demonstrating that substitution of the secondary hydroxyl group with f

Full text of DOI:10.1021/jm00380a019

Products guided by the article

Product name:N-[1-(tert-Butyl-dimethyl-silanyloxymethyl)-2-fluoro-2-(4-nitro-phenyl)-ethyl]-2,2-dichloro-acetamide

Cas No:93863-38-8

R&D Labs maybe for 93863-38-8

Jurong Huaheng Natural Biological Products Factory

website:http://www.risebiochem.com

Contact:+86-13921007726

Address:Chuncheng town,Jurong city,Jiangsu province,China
Changsha Nutritopper Bio Technology Co.,Ltd.

Contact:+86-731-87803543

Address:East 1st Street, Baima Road, Ningxiang County
Jiangxi Province Bethel Pharmaceutical Co., Ltd.

Contact:+86-795-259 3456 ，+86-15957688008 13566650571

Address:Huangjindui Chemical Park， Shanggao County ，Yichun city，Jiangxi Province
Shanghai Yuking Water Soluble Material Tech Co., Ltd

Contact:86-21-68286299

Address:4F, 13B, No. 600, South Xinyuan Road 201306, Shanghai, China
Shaanxi Lighte Optoelectronics Material Co., Ltd.

Contact:+86-29-88320728-622/619/620

Address:No.55 INDUSTRY ROAD 2,XI'AN NATIONAL CIVIL AEROSPACE INDUSTRIAL PARK.XI'AN China 710065.

Relevant to this article

Doi:10.1021/ja00876a043
(1962)
Tuning the reactivity of osmium(II) and ruthenium(II) arene complexes under physiological conditions

Doi:10.1021/ja055886r
(2006)
A new modular and flexible approach to [1,2,3]triazolo[1,5-a][1,4]benzodiazepines

Doi:10.1016/j.tetlet.2007.03.121
(2007)
Sustainable synthesis of 1,2,3,4-cyclohexanetetracarboxylate from sugar-derived carboxylic acids

Doi:10.1039/d0cc02163f
(2020)
Synthesis of (-)-homogalanthamine from naltrexone

Doi:10.1021/jo1022487
(2011)
Zirconocene dichloride catalyzed hydrodefluorination of C sp 2-F bonds

Doi:10.1002/anie.201207036
(2012)

Article Doi