Fluorine-Containing Amino Acids and Their Derivatives. 4. Synthesis and Antibacterial Activity of Threo and Erythro 1-Fluorodehydroxylated Chloramphenicol Analogues

DOI: 10.1021/jm00380a019

Source and publish data:

Journal of Medicinal Chemistry p. 253 - 256 (1985)

Update date:2022-08-06

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Authors:

Tsushima, Tadahiko

Kawada, Kenji

Tsuji, Teruji

Tawara, Katsuya

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Article abstract of DOI:10.1021/jm00380a019

Both threo and erythro 1-fluorodehydroxylated chloramphenicol analogues were synthesized and tested for antimicrobial activity.None showed antibacterial or antifungal activity, clearly demonstrating that substitution of the secondary hydroxyl group with f

Full text of DOI:10.1021/jm00380a019

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