143.33, 139.63, 132.46, 130.30, 129.92, 121.06, 118.37, 110.62, 106.44, 68.66, 60.11,
56.62, 56.11, 42.46. HR-MS (ESI):Calcd. C29H32N5O5S2, [M+H]+m/z: 594.1845,
found: 594.1849.
4.3.9(E)-2-oxo-2-((4-(3-(3,4,5-trimethoxyphenyl)acryloyl)phenyl)am
ino)ethyl -4-butylpiperazine-1-carbodithioate (12h)
1
Yellow solid; M.p.: 130~132oC; Yield: 82%. H NMR (400 MHz, DMSO-d6) δ 10.69
(s, 1H), 8.19 (d, J = 8.8 Hz, 2H), 7.91 (d, J = 15.5 Hz, 1H), 7.81 (d, J = 8.8 Hz, 2H),
7.70 (d, J = 15.5 Hz, 1H), 7.24 (s, 2H), 4.33 (s, 2H), 4.21 (s, 2H), 3.95 (s, 2H), 3.88 (s,
6H), 3.73 (s, 3H), 2.45 (s, 4H), 2.33 – 2.25 (m, 2H), 1.45-1.38 (m, 2H), 1.34-1.25 (m,
2H), 0.88 (t, J = 7.3 Hz, 3H). 13C NMR (100 MHz, DMSO-d6) δ 194.14, 187.40,
165.98, 153.08, 143.88, 143.34, 139.64, 132.46, 130.30, 129.90, 121.06, 118.36,
106.44, 60.10, 56.84, 56.10, 52.15, 41.30, 28.36, 19.99, 13.84. HR-MS (ESI):Calcd.
C29H38N3O5S2, [M+H]+m/z: 572.2253, found: 572.2258.
4.3.10(E)-2-oxo-2-((4-(3-(3,4,5-trimethoxyphenyl)acryloyl)phenyl)a
mino)ethyl -4-(methylsulfonyl)piperazine-1-carbodithioate (12i)
1
Yellow solid; M.p.: 183~185oC; Yield: 62%. H NMR (400 MHz, DMSO-d6) δ 10.70
(s, 1H), 8.18 (d, J = 8.8 Hz, 2H), 7.90 (d, J = 15.5 Hz, 1H), 7.79 (d, J = 8.8 Hz, 2H),
7.68 (d, J = 15.5 Hz, 1H), 7.23 (s, 2H), 4.35 (s, 2H), 4.32 (s, 2H), 4.13 (s, 2H), 3.87 (s,
6H), 3.72 (s, 3H), 3.29 (s, 4H), 2.95 (s, 3H). 13C NMR (100 MHz, DMSO-d6) δ
195.35, 187.42, 165.84, 153.08, 143.90, 143.31, 139.64, 132.47, 130.29, 129.93,
121.07, 118.36, 106.46, 60.11, 56.12, 44.87, 41.41, 34.40. HR-MS (ESI):Calcd.
C26H32N3O7S3, [M+H]+m/z: 594.1402, found: 594.1407.
4.3.11(E)-2-oxo-2-((4-(3-(3,4,5-trimethoxyphenyl)acryloyl)phenyl)a
mino)ethyl- morpholine-4-carbodithioate (12j)
1
Yellow solid; M.p.: 176~178oC; Yield: 60%. H NMR (400 MHz, DMSO-d6) δ 10.70
(s, 1H), 8.18 (d, J = 8.6 Hz, 2H), 7.90 (d, J = 15.5 Hz, 1H), 7.80 (d, J = 8.6 Hz, 2H),
7.69 (d, J = 15.5 Hz, 1H), 7.23 (s, 2H), 4.35 (s, 2H), 4.21 (s, 2H), 4.08 – 3.94 (m, 2H),
3.87 (s, 6H), 3.72 (s, 3H), 3.70 (s, 4H). 13C NMR (100 MHz, DMSO-d6) δ 194.90,
187.45, 165.96, 153.07, 143.91, 143.31, 139.61, 132.45, 130.29, 129.92, 121.06,
118.38, 106.41, 65.53, 60.11, 56.10, 55.63, 41.09. HR-MS (ESI):Calcd. C25H29N2O6S2,
[M+H]+m/z: 517.1467, found: 517.1469.
4.3.12(E)-2-oxo-2-((4-(3-(3,4,5-trimethoxyphenyl)acryloyl)phenyl)a
mino)ethyl -thiomorpholine-4-carbodithioate 1,1-dioxide (12k)
1
Yellow solid; M.p.: 179~181oC; Yield: 74%. H NMR (400 MHz, DMSO-d6) δ 10.74
(s, 1H), 8.20 (d, J = 8.7 Hz, 2H), 7.91 (d, J = 15.5 Hz, 1H), 7.81 (d, J = 8.7 Hz, 2H),
7.70 (d, J = 15.5 Hz, 1H), 7.24 (s, 2H), 4.57 (s, 4H), 4.37 (s, 2H), 3.88 (s, 6H), 3.73 (s,
13
3H), 3.38 (s, 4H). C NMR (100 MHz, DMSO-d6) δ 197.10, 187.44, 165.62, 153.07,
143.91, 143.23, 139.64, 132.54, 130.29, 129.93, 121.06, 118.43, 106.44, 60.11, 56.10,
50.54, 42.24, 29.56. HR-MS (ESI):Calcd. C25H29N2O7S3, [M+H]+m/z: 565.1137,