Synthesis and antibacterial activity of 1-(2-fluorovinyl)-7-substituted-4- quinolone-3-carboxylic acid derivatives, conformationally restricted analogues of fleroxacin

DOI: 10.1021/jm0402061

Source and publish data:

Journal of Medicinal Chemistry p. 3194 - 3202 (2005)

Update date:2022-07-29

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Authors:

Asahina, Yoshikazu

Iwase, Kazuhiko

Iinuma, Fujio

Hosaka, Masaki

Ishizaki, Takayoshi

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Article abstract of DOI:10.1021/jm0402061

The novel 1-(2-fluorovinyl)-4-quinolone-3-carboxylic acid derivatives Z-15a-c, E-15a-c, Z-16a-c, and E-16a-c, conformationally restricted analogues of fleroxacin (5), were synthesized, and their in vitro antibacterial activity was evaluated. A dehydrosulf

Full text of DOI:10.1021/jm0402061

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