Journal of the American Chemical Society p. 1698 - 1701 (1985)
Update date:2022-08-04
Topics:
Overman, Larry E.
Osawa, Tatsushi
The reaction of lithium ester enolates with N-(cyanomethyl)amines affords 4-unsubstituted β-lactams in good yields, see eq 1.The N-1 substituent can be varied widely, as can the C-3 substituents, which can be H, alkyl, SPh, NH2, or NHCOR.The preparation o
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