HIGHLY STEREOSELECTIVE REDUCTION OF α-METHYLTHIO AND α-PHENYLTHIO KETONES---SYNTHESIS OF syn- AND anti-β-METHYLTHIO- AND β-PHENYLTHIOALCOHOLS---

Article abstract of DOI:10.1016/S0040-4039(01)81516-1

Reduction of α-methylthio and α-phenylthio ketones 1 with L- selectride gave syn-alcohols 2 in high stereoselectivity except when R1 was cyclohexyl group, while reduction with Zn(BH4)2 gave the isomeric anti-alcohols 3 provided R3 was a methyl group.