Enantioselective syntheses of (-)-pinellic acid, α- and β-dimorphecolic acid

Article abstract of DOI:10.1016/j.tet.2007.05.047

An efficient enantioselective convergent approach for the synthesis of (-)-pinellic acid 1, α- and β-dimorphecolic acid (2 and 3) from 1,9-nonane diol is described. The synthetic strategy features Sharpless asymmetric hydroxylation, Sonogashira coupling and Birch reduction.