Organic and Biomolecular Chemistry p. 430 - 433 (2015)
Update date:2022-08-04
Topics:
Due-Hansen, Maria E.
Pandey, Sunil K.
Christiansen, Elisabeth
Andersen, Rikke
Hansen, Steffen V. F.
Ulven, Trond
A protocol for amide coupling by in situ formation of acyl fluorides and reaction with amines at elevated temperature has been developed and found to be efficient for coupling of sterically hindered substrates and electron deficient amines where standard methods failed.
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