Bioorganic and Medicinal Chemistry Letters p. 505 - 510 (1998)
Update date:2022-08-03
Topics:
Segarra, Victor
Crespo, M. Isabel
Pujol, Ferran
Beleta, Jorge
Domenech, Teresa
Miralpeix, Montserrat
Palacios, Jose M.
Castro, Ana
Martinez, Ana
A 4-centre PDE 4 pharmacophore search has been carried out in several 3D-databases containing compounds belonging to different therapeutic areas. Losartan, an angiotensin-II antagonist, has been identified as a new lead compound for developing PDE 4 inhibitors. New families of compounds derived from losartan has been synthesized and their PDE inhibition has been measured.
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