Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds

DOI: 10.1016/S0960-894X(98)00058-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 505 - 510 (1998)

Update date:2022-08-03

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Authors:

Segarra, Victor

Crespo, M. Isabel

Pujol, Ferran

Beleta, Jorge

Domenech, Teresa

Miralpeix, Montserrat

Palacios, Jose M.

Castro, Ana

Martinez, Ana

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Article abstract of DOI:10.1016/S0960-894X(98)00058-4

A 4-centre PDE 4 pharmacophore search has been carried out in several 3D-databases containing compounds belonging to different therapeutic areas. Losartan, an angiotensin-II antagonist, has been identified as a new lead compound for developing PDE 4 inhibitors. New families of compounds derived from losartan has been synthesized and their PDE inhibition has been measured.

Full text of DOI:10.1016/S0960-894X(98)00058-4

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