Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds

DOI: 10.1016/S0960-894X(98)00058-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 505 - 510 (1998)

Update date:2022-08-03

Topics:

Authors:

Segarra, Victor

Crespo, M. Isabel

Pujol, Ferran

Beleta, Jorge

Domenech, Teresa

Miralpeix, Montserrat

Palacios, Jose M.

Castro, Ana

Martinez, Ana

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00058-4

A 4-centre PDE 4 pharmacophore search has been carried out in several 3D-databases containing compounds belonging to different therapeutic areas. Losartan, an angiotensin-II antagonist, has been identified as a new lead compound for developing PDE 4 inhibitors. New families of compounds derived from losartan has been synthesized and their PDE inhibition has been measured.

Full text of DOI:10.1016/S0960-894X(98)00058-4

Products guided by the article

Product name:2-(butyramido)-5-methylbenzoic acid

Cas No:950236-50-7

R&D Labs maybe for 950236-50-7

Tianjin Boron PharmaTech Co.,Ltd.(expird)

Contact:86-022-59845187

Address:B9-401, Tianda Science Park,No.80,4th Avenue,TEDA,Tianjin, China
ZUNYI CITY BEI YUAN CHEMICAL CO., LTD

website:http://www.china-beiyuan.com

Contact:+86-851-27751258

Address:Shawan Town, Huichuan District, Zunyi City, Guizhou Province, China
SunaTech Inc.

Contact:+86 512 6287 2180

Address:398 Ruoshui Road, Suzhou Industrial Park, Suzhou, Jiangsu, P. R. China
PharmOrgsyn

Contact:+86-21-38228826

Address:Room 505 Building 2, No 3377 Kangxin Highway, Shanghai, Republic China
WEIFANG DERUN CHEMICAL CO.,LTD

Contact:86-536-8956886

Address:weifang

Relevant to this article

Synthesis and properties of (6-methyl-2-oxo-4-thioxo-1,2,3,4-tetrahydro-3- pyrimidinyl)acetic acid methyl ester

Doi:10.1007/s10593-007-0073-2
(2007)
Synthesis of bicyclic 1,4-thiazepines as novel anti-: Trypanosoma brucei brucei agents

Doi:10.1039/c9md00064j
(2019)
Stereodivergent catalytic doubly diastereoselective nitroaldol reactions using heterobimetallic complexes

Doi:10.1021/ol800653d
(2008)
Condensation of 4-aryl-4-oxobutanoic acids with benzylamines: Synthetic and structural studies on 1-arylmethyl-3-[(E)-1-arylmethylidene]-5-phenyl-2,3- dihydro-1H-2-pyrrolones

Doi:10.1007/s10593-007-0044-7
(2007)
Carbon-Carbon Bond Cleavage during Silane Reductions of the Dimer of 2-Phenylisophosphindole Oxide

Doi:10.1021/jo00366a041
(1986)
Use of the benzyl mesylate for the synthesis of tetrahydrofuran lignan: Syntheses of 7,8-trans, 7′,8′-trans, 7,7′-cis, and 8,8′-cis-virgatusin stereoisomers

Doi:10.1271/bbb.70236
(2007)

Article Doi