Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds

DOI: 10.1016/S0960-894X(98)00058-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 505 - 510 (1998)

Update date:2022-08-03

Topics:

Authors:

Segarra, Victor

Crespo, M. Isabel

Pujol, Ferran

Beleta, Jorge

Domenech, Teresa

Miralpeix, Montserrat

Palacios, Jose M.

Castro, Ana

Martinez, Ana

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00058-4

A 4-centre PDE 4 pharmacophore search has been carried out in several 3D-databases containing compounds belonging to different therapeutic areas. Losartan, an angiotensin-II antagonist, has been identified as a new lead compound for developing PDE 4 inhibitors. New families of compounds derived from losartan has been synthesized and their PDE inhibition has been measured.

Full text of DOI:10.1016/S0960-894X(98)00058-4

Products guided by the article

Product name:2-(butyramido)-5-methylbenzoic acid

Cas No:950236-50-7

R&D Labs maybe for 950236-50-7

Jiangxi Province Bethel Pharmaceutical Co., Ltd.

Contact:+86-795-259 3456 ，+86-15957688008 13566650571

Address:Huangjindui Chemical Park， Shanggao County ，Yichun city，Jiangxi Province
SuZhou LaiTeou

Contact:+86-0512-88957371

Address:shanghai
PharmaResources(Kaiyuan)CO,.Ltd

Contact:+86-21-50720028

Address:No.3, Beihuan Road, Economic Development District, Kaiyuan City, Tieling City, Liaoning Province, China 112300
Cangzhou Senary Chemical Science-tech Co., Ltd

Contact:+86-317-3563899, 3563699

Address:168 Jinde Road, Cangzhou, Hebei, China
VanderArk International Limited

Contact:86-10-82437576

Address:Qing He

Relevant to this article

Synthesis and properties of (6-methyl-2-oxo-4-thioxo-1,2,3,4-tetrahydro-3- pyrimidinyl)acetic acid methyl ester

Doi:10.1007/s10593-007-0073-2
(2007)
Synthesis of bicyclic 1,4-thiazepines as novel anti-: Trypanosoma brucei brucei agents

Doi:10.1039/c9md00064j
(2019)
Stereodivergent catalytic doubly diastereoselective nitroaldol reactions using heterobimetallic complexes

Doi:10.1021/ol800653d
(2008)
Condensation of 4-aryl-4-oxobutanoic acids with benzylamines: Synthetic and structural studies on 1-arylmethyl-3-[(E)-1-arylmethylidene]-5-phenyl-2,3- dihydro-1H-2-pyrrolones

Doi:10.1007/s10593-007-0044-7
(2007)
Carbon-Carbon Bond Cleavage during Silane Reductions of the Dimer of 2-Phenylisophosphindole Oxide

Doi:10.1021/jo00366a041
(1986)
Use of the benzyl mesylate for the synthesis of tetrahydrofuran lignan: Syntheses of 7,8-trans, 7′,8′-trans, 7,7′-cis, and 8,8′-cis-virgatusin stereoisomers

Doi:10.1271/bbb.70236
(2007)

Article Doi