Chemical and Pharmaceutical Bulletin p. 3561 - 3568 (1984)
Update date:2022-08-05
Topics:
Hashigaki
Hiramatsu
Yamato
Tasaka
Various 1'-(o, m, and/or p-substituted benzyl) (5), 1'-(heterocyclic arylmethyl) (6), and 1'-acyl (7) analogs of spiro[isochroman-3,4'-piperidin]-1-one were prepared and tested for inhibitory activity on the compound 48/80-induced release of histamine from mast cells. The biological results suggested that the activity is mainly affected by the lipophilicity rather than by the electrostatic character of the 1'-substituent. 4-Benzylspiro[cyclohexane-1,3'-hexahydroisochroman]-1'-one (17) and 9-benzyl-1-oxa-spiro[5.5]undecan-2-one (18) were prepared and found to be inactive, implying that the benzene moiety in the isochroman ring is essential for the activity.
View MoreShanghai Synmedia Chemical Co., Ltd
Contact:+86-21-38681880
Address:6th Floor, 11A Building, No.528 Ruiqing Road, Heqing town, Pudong new district, Shanghai China
Contact:+86-28-88523492
Address:714rooms of Time Square, Pujiang County
website:http://www.ringchemicals.com/
Contact:+1-416-493-6870
Address:Toronto, Canada
website:http://www.oceanchem-group.com
Contact:86-536-8596048
Address:9th floor,Building B future Plaza, No.88.Fenghuang Street,Weifang,Shandong,China
Contact:0086 371 65711996
Address:Jalan 4/3, Kawasan Perindustrian Serendah, 48000 Rawang,
Doi:10.1016/S0040-4039(01)81677-4
(1984)Doi:10.1021/jo00207a055
(1985)Doi:10.1039/b707957e
(2007)Doi:10.1016/S0040-4039(01)91394-2
(1984)Doi:10.1021/jo7017813
(2007)Doi:10.1021/ja0724590
(2007)
