Nocathiacin analogs: Synthesis and antibacterial activity of novel water-soluble amides

DOI: 10.1016/j.bmcl.2009.04.144

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3531 - 3535 (2009)

Update date:2022-07-29

Topics:

Authors:

Xu, Libo

Farthing, Amy K.

Dropinski, James F.

Meinke, Peter T.

McCallum, Christine

Leavitt, Penny S.

Hickey, Emily J.

Colwell, Lawrence

Barrett, John

Liu, Kun

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Article abstract of DOI:10.1016/j.bmcl.2009.04.144

Novel water-soluble amide analogs were synthesized from nocathiacin I (1) through the formation of the carboxylic acid intermediate followed by coupling to primary or secondary amines. Several compounds with potent antibacterial activity and adequate wate

Full text of DOI:10.1016/j.bmcl.2009.04.144

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