Journal of Medicinal Chemistry p. 914 - 921 (1985)
Update date:2022-07-30
Topics:
Taylor, Edward C.
Harrington, Peter J.
Fletcher, Stephen R.
Beardsley, G. Peter
Moran, Richard, G.
Total syntheses from pyridine precursors of 5,10-dideazaaminopterin (1) and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin (2) are described.These compounds exhibit significant in vivo activity against L1210 leukemia that comparable to that observed with meth
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