Synthesis of the Antileucemic Agents 5,10-Dideazaaminopterin and 5,10-Dideaza-5,6,7,8-tetrahydroaminopterin

DOI: 10.1021/jm00145a012

Source and publish data:

Journal of Medicinal Chemistry p. 914 - 921 (1985)

Update date:2022-07-30

Topics:

Authors:

Taylor, Edward C.

Harrington, Peter J.

Fletcher, Stephen R.

Beardsley, G. Peter

Moran, Richard, G.

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Article abstract of DOI:10.1021/jm00145a012

Total syntheses from pyridine precursors of 5,10-dideazaaminopterin (1) and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin (2) are described.These compounds exhibit significant in vivo activity against L1210 leukemia that comparable to that observed with meth

Full text of DOI:10.1021/jm00145a012

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