UNE NOUVELLE METHODE DE SYNTHESE PEPTIDIQUE INTRAMOLECULAIRE, APPLICABLE A LA SARCOSINE, A L'AIDE DE DERIVES DE L'ACIDE OXALIQUE

Article abstract of DOI:10.1016/S0040-4020(01)91263-3

Two steps are postulated in a new method of intramolecular peptide synthesis using oxalic acid derivates (Fig. 1).Both are verified with model derivatives incorporating one sarcosine residue: cyclisation of 2d into 5 (Fig. 4) and aminolysis of 5 leading t