Chiral Synthesis of the Key Intermediates of (+)- and (-)-Thienamycin

Article abstract of DOI:10.1021/jo00213a025

Synthesis of the optically active β-keto ester 11a, the key intermediate in the preparation of (+)-thienamycin, has been achieved.An enantioselective <3 + 2> cycloaddition of the chiral nitrone with benzyl crotonate was employed as a key reaction.