Metabolites of Cibenzoline: Synthesis of Hydroxylated 1,1-Diphenyl-2-imidazolylcyclopropanes and 5,5-Diphenyl-2H-pyrroloimidazolines

DOI: 10.1021/jo00213a004

Source and publish data:

Journal of Organic Chemistry p. 2220 - 2224 (1985)

Update date:2022-08-05

Topics:

Authors:

Tilley, Jefferson W.

Clader, John W.

Wirkus, Maria

Blount, John F.

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Article abstract of DOI:10.1021/jo00213a004

The (hydroxyphenyl)pyrrolo<1,2-a>imidazolines 7a and 7b, which are of interest as oxidative metabolites of the antiarrhythmic agent cibenzoline (1), were synthesized by the base-catalyzed rearrangement of the cyclopropylphenols derived from benzyl ethers

Full text of DOI:10.1021/jo00213a004

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