Metabolites of Cibenzoline: Synthesis of Hydroxylated 1,1-Diphenyl-2-imidazolylcyclopropanes and 5,5-Diphenyl-2H-pyrroloimidazolines

Article abstract of DOI:10.1021/jo00213a004

The (hydroxyphenyl)pyrrolo<1,2-a>imidazolines 7a and 7b, which are of interest as oxidative metabolites of the antiarrhythmic agent cibenzoline (1), were synthesized by the base-catalyzed rearrangement of the cyclopropylphenols derived from benzyl ethers