STEREOSPECIFIC SYNTHESIS OF (25R)-26-HYDROXYCHOLESTEROL VIA SIGMATROPIC REARRANGEMENT. A NEW STEREOSELECTIVE TWO-CARBON HOMOLOGATION OF 20-KETO STEROIDS TO THE 23-ALDEHYDE.

DOI: 10.1016/S0040-4039(01)80842-X

Source and publish data:

Tetrahedron Letters p. 5021 - 5024 (1985)

Update date:2022-08-03

Topics:

Authors:

Midland, M. Mark

Kwon, Young C.

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Article abstract of DOI:10.1016/S0040-4039(01)80842-X

Pregnenolone was stereoselectively converted into (25R)-26-hydroxycholesterol using a stereoselective hydroboration, assymetric reduction and a strereospecific <2.3> sigmatropic rearrangement as key steps.

Full text of DOI:10.1016/S0040-4039(01)80842-X

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