Synthesis and biological activity of pentapeptide analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline

DOI: 10.1021/jm00146a014

Source and publish data:

Journal of Medicinal Chemistry p. 1062 - 1066 (1985)

Update date:2022-08-04

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Authors:

Almquist

Jennings-White

Chao Chao

Steeger Steeger

Wheeler Wheeler

Rogers Rogers

Mitoma Mitoma

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Article abstract of DOI:10.1021/jm00146a014

Two pentapeptide analogues (14 and 15) of the ketomethylene-containing angiotensin converting enzyme (ACE) inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline (1) were synthesized and evaluated as ACE inhibitors and antihypertensive agents. Compound

Full text of DOI:10.1021/jm00146a014

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