Synthesis and Biological Activity of Substituted oxy>acetic Acids. A New Class of Heteroatom-Activated β-Lactam Antibiotics

DOI: 10.1021/jm00148a013

Source and publish data:

Journal of Medicinal Chemistry p. 1447 - 1453 (1985)

Update date:2022-08-04

Topics: Synthesis Substituted β-Lactam Biological Activity Experimental Antibiotics

Authors:

Woulfe, Steven R.

Miller, Marvin J.

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Article abstract of DOI:10.1021/jm00148a013

The synthesis of substituted <<3(S)-(acylamino)-2-oxo-1-azetidinyl>oxy>acetic acids (1) is described. 3-<(Carbobenzyloxy)amino>-N-hydroxy-2-azetidinones (13a, b), prepared from serine and threonine, were alkylated with 2-(trimethylsilyl)ethyl bromoacetate

Full text of DOI:10.1021/jm00148a013

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