REACTION OF N-ALKYLTHIAZOLIUM HALIDES, INCLUDING THIAMINE, WITH SUPEROXIDE ION. CHEMISTRY AND BIOLOGICAL IMPLICATIONS.

Article abstract of DOI:10.1016/S0040-4039(00)98871-3

N-alkylthiazolium halides are transformed by KO2 into the corresponding thiazolin-2-ones and thiazolin-2-thiones; the same reactions occur with thiamine, whose thiazolin-2-one pyrophosphate has been reported to be a strong inhibitor of pyruvic dehydrogenase.