
Chemistry Letters p. 949 - 952 (1985)
Update date:2022-08-04
Topics:
Mitsunobu, Oyo
Takahashi, Miyako
Seki, Hiroshi
Arai, Makoto
Yasumoto, Fumiko
et al.
The reagent formed by the reaction of 2-chlorophenyl phosphorodichloridate with 2 molar amounts of 5-nitrobenzotriazole was allowed to react successively with nucleosides having free 3'-hydroxyl groups and nucleosides having free 5'-hydroxyl groups affording the corresponding dinucleoside phosphates in 63-97 percent yields.
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