A CONVENIENT PROCEDURE FOR THE PREPARATION OF DINUCLEOSIDE PHOSPHATES BY THE USE OF A BIFUNCTIONAL PHOSPHORYLATING REAGENTS, 2-CHLOROPHENYLPHOSPHOROBIS(NITROBENZOTRIAZOLIDE)

DOI: 10.1246/cl.1985.949

Source and publish data:

Chemistry Letters p. 949 - 952 (1985)

Update date:2022-08-04

Topics:

Authors:

Mitsunobu, Oyo

Takahashi, Miyako

Seki, Hiroshi

Arai, Makoto

Yasumoto, Fumiko

et al. et al.

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Article abstract of DOI:10.1246/cl.1985.949

The reagent formed by the reaction of 2-chlorophenyl phosphorodichloridate with 2 molar amounts of 5-nitrobenzotriazole was allowed to react successively with nucleosides having free 3'-hydroxyl groups and nucleosides having free 5'-hydroxyl groups affording the corresponding dinucleoside phosphates in 63-97 percent yields.

Full text of DOI:10.1246/cl.1985.949

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