Journal of the Chemical Society. Perkin transactions II p. 337 - 340 (1984)
Update date:2022-08-11
Topics:
Temerk, Yassien M.
Kamal, Mostafa M.
Ahmed, Mohamed E.
The rates of hydrolysis of a series of substituted benzylidenesalicylohydrazide derivatives 40percent (v/v) ethanol-buffer mixture have been investigated by differential pulse polarography.The hydrolysis is catalysed by H+ and its rate follows strictly first-order kinetics.The rate constant decreases with increasing pH up to around pH 3.9, beyond which no measurable reaction was observed; here the protonation of imine begins to be significantly incomplete.The attack of water on the protonated substrate is considered to be the rate-determining step.The effects of pH, molecular structure, and temperature on the reaction rate and the activation energy are reported.Thermodynamic parameters (ΔG(formula), ΔH(formula), and ΔS(fomula)) for the hydrolysis are discussed.
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